Remdesivir and EIDD-1931 Interact with Human Equilibrative Nucleoside Transporters 1 and 2: Implications for Reaching SARS-CoV-2 Viral Sanctuary Sites.

Adenosine Monophosphate / administration & dosage Alanine / administration & dosage Antiviral Agents / administration & dosage COVID-19 / metabolism Cytidine / administration & dosage Dose-Response Relationship, Drug Drug Interactions / physiology Equilibrative Nucleoside Transporter 1 / metabolism Equilibrative-Nucleoside Transporter 2 / metabolism HeLa Cells Humans Protein Binding / drug effects SARS-CoV-2 / drug effects COVID-19 Drug Treatment

Journal

Molecular pharmacology
ISSN: 1521-0111
Titre abrégé: Mol Pharmacol
Pays: United States
ID NLM: 0035623

Informations de publication

Date de publication:
12 2021
Historique:
received: 07 06 2021
accepted: 07 09 2021
pubmed: 11 9 2021
medline: 30 11 2021
entrez: 10 9 2021
Statut: ppublish

Résumé

Equilibrative nucleoside transporters (ENTs) are present at the blood-testis barrier (BTB), where they can facilitate antiviral drug disposition to eliminate a sanctuary site for viruses detectable in semen. The purpose of this study was to investigate ENT-drug interactions with three nucleoside analogs, remdesivir, molnupiravir, and molnupiravir's active metabolite,

Identifiants

DOI: 10.1124/molpharm.121.000333 PMID: 34503974 PMC: PMC8626781
pubmed: 34503974
pii: molpharm.121.000333
doi: 10.1124/molpharm.121.000333
pmc: PMC8626781
doi:

Substances chimiques

Antiviral Agents 0
Equilibrative Nucleoside Transporter 1 0
Equilibrative-Nucleoside Transporter 2 0
SLC29A1 protein, human 0
SLC29A2 protein, human 0
remdesivir 3QKI37EEHE
Adenosine Monophosphate 415SHH325A
Cytidine 5CSZ8459RP
N(4)-hydroxycytidine C3D11PV2O4
Alanine OF5P57N2ZX

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

548-557

Subventions

Organisme : NIEHS NIH HHS
ID : T32 ES007091
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM123643
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES006694
Pays : United States
Organisme : NIGMS NIH HHS
ID : R41 GM131433
Pays : United States
Organisme : NIGMS NIH HHS
ID : R44 GM122196
Pays : United States

Commentaires et corrections

Type : CommentIn
Type : CommentIn

Informations de copyright

Copyright © 2021 by The American Society for Pharmacology and Experimental Therapeutics.

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Auteurs

Siennah R Miller (SR)

College of Pharmacy, Department of Pharmacology & Toxicology (S.R.M., M.E.M., N.J.C.) and Department of Physiology (S.H.W.), University of Arizona, Tucson, Arizona; and Collaborations Pharmaceuticals, Inc., Raleigh, North Carolina (K.M.Z., S.E.).

Meghan E McGrath (ME)

College of Pharmacy, Department of Pharmacology & Toxicology (S.R.M., M.E.M., N.J.C.) and Department of Physiology (S.H.W.), University of Arizona, Tucson, Arizona; and Collaborations Pharmaceuticals, Inc., Raleigh, North Carolina (K.M.Z., S.E.).

Kimberley M Zorn (KM)

College of Pharmacy, Department of Pharmacology & Toxicology (S.R.M., M.E.M., N.J.C.) and Department of Physiology (S.H.W.), University of Arizona, Tucson, Arizona; and Collaborations Pharmaceuticals, Inc., Raleigh, North Carolina (K.M.Z., S.E.).

Sean Ekins (S)

College of Pharmacy, Department of Pharmacology & Toxicology (S.R.M., M.E.M., N.J.C.) and Department of Physiology (S.H.W.), University of Arizona, Tucson, Arizona; and Collaborations Pharmaceuticals, Inc., Raleigh, North Carolina (K.M.Z., S.E.).

Stephen H Wright (SH)

College of Pharmacy, Department of Pharmacology & Toxicology (S.R.M., M.E.M., N.J.C.) and Department of Physiology (S.H.W.), University of Arizona, Tucson, Arizona; and Collaborations Pharmaceuticals, Inc., Raleigh, North Carolina (K.M.Z., S.E.).

Nathan J Cherrington (NJ)

College of Pharmacy, Department of Pharmacology & Toxicology (S.R.M., M.E.M., N.J.C.) and Department of Physiology (S.H.W.), University of Arizona, Tucson, Arizona; and Collaborations Pharmaceuticals, Inc., Raleigh, North Carolina (K.M.Z., S.E.) cherrington@pharmacy.arizona.edu.

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › AMP › Remdesivir and EIDD-1931 Interact with Human...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Alanine › Remdesivir and EIDD-1931 Interact with Human...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Remdesivir and EIDD-1931 Interact with Human...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Remdesivir and EIDD-1931 Interact with Human...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Cytidine › Remdesivir and EIDD-1931 Interact with Human...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Remdesivir and EIDD-1931 Interact with Human...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Interactions médicamenteuses › Remdesivir and EIDD-1931 Interact with Human...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteurs équilibrants de nucléosides › Transporteur équilibrant de nucléosides de type 1 › Remdesivir and EIDD-1931 Interact with Human...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteurs équilibrants de nucléosides › Transporteur équilibrant de nucléosides de type 2 › Remdesivir and EIDD-1931 Interact with Human...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HeLa › Remdesivir and EIDD-1931 Interact with Human...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Remdesivir and EIDD-1931 Interact with Human...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Remdesivir and EIDD-1931 Interact with Human...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Remdesivir and EIDD-1931 Interact with Human...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Traitements médicamenteux de la COVID-19 › Remdesivir and EIDD-1931 Interact with Human...