Out-of-Equilibrium Biophysical Chemistry: The Case for Multidimensional, Integrated Single-Molecule Approaches.
Journal
The journal of physical chemistry. B
ISSN: 1520-5207
Titre abrégé: J Phys Chem B
Pays: United States
ID NLM: 101157530
Informations de publication
Date de publication:
23 09 2021
23 09 2021
Historique:
pubmed:
11
9
2021
medline:
21
10
2021
entrez:
10
9
2021
Statut:
ppublish
Résumé
Out-of-equilibrium processes are ubiquitous across living organisms and all structural hierarchies of life. At the molecular scale, out-of-equilibrium processes (for example, enzyme catalysis, gene regulation, and motor protein functions) cause biological macromolecules to sample an ensemble of conformations over a wide range of time scales. Quantifying and conceptualizing the structure-dynamics to function relationship is challenging because continuously evolving multidimensional energy landscapes are necessary to describe nonequilibrium biological processes in biological macromolecules. In this perspective, we explore the challenges associated with state-of-the-art experimental techniques to understanding biological macromolecular function. We argue that it is time to revisit how we probe and model functional out-of-equilibrium biomolecular dynamics. We suggest that developing integrated single-molecule multiparametric force-fluorescence instruments and using advanced molecular dynamics simulations to study out-of-equilibrium biomolecules will provide a path towards understanding the principles of and mechanisms behind the structure-dynamics to function paradigm in biological macromolecules.
Identifiants
pubmed: 34506140
doi: 10.1021/acs.jpcb.1c02424
pmc: PMC8474109
doi:
Substances chimiques
Macromolecular Substances
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
10404-10418Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM121342
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH081923
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM119691
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM131959
Pays : United States
Organisme : NIAID NIH HHS
ID : R15 AI137979
Pays : United States
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