α-tocopherol, a slow-binding inhibitor of acetylcholinesterase.

Acetylcholinesterase / chemistry Cholinesterase Inhibitors / metabolism Humans Kinetics Models, Molecular Phosphorylation Protein Conformation alpha-Tocopherol / metabolism
Acetylcholinesterase Molecular modeling Organophosphorus Slow-binding inhibition α-tocopherol

Journal

Chemico-biological interactions
ISSN: 1872-7786
Titre abrégé: Chem Biol Interact
Pays: Ireland
ID NLM: 0227276

Informations de publication

Date de publication:
01 Oct 2021
Historique:
received: 27 05 2021
revised: 03 08 2021
accepted: 06 09 2021
pubmed: 11 9 2021
medline: 1 10 2021
entrez: 10 9 2021
Statut: ppublish

Résumé

Acetylcholinesterase (AChE) is reversibly inhibited by α-tocopherol (α-T). Steady state kinetic analysis shows that α-T is a mixed slow-binding inhibitor of type A of human enzyme (K

Identifiants

DOI: 10.1016/j.cbi.2021.109646 PMID: 34506764
pubmed: 34506764
pii: S0009-2797(21)00284-2
doi: 10.1016/j.cbi.2021.109646
pii:
doi:

Substances chimiques

Cholinesterase Inhibitors 0
Acetylcholinesterase EC 3.1.1.7
alpha-Tocopherol H4N855PNZ1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

109646

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Irina Zueva (I)

Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center "Kazan Scientific Center of the Russian Academy of Sciences", Arbuzov str., 8, Kazan, 420088, Russian Federation.

Sofya Lushchekina (S)

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Kosygin str 4, Moscow, 119334, Russian Federation.

Polina Shulnikova (P)

Kazan Federal University, Neuropharmacology Laboratory, Kremlevskaya str 18, 480002, Kazan, Russian Federation.

Oksana Lenina (O)

Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center "Kazan Scientific Center of the Russian Academy of Sciences", Arbuzov str., 8, Kazan, 420088, Russian Federation.

Konstantin Petrov (K)

Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center "Kazan Scientific Center of the Russian Academy of Sciences", Arbuzov str., 8, Kazan, 420088, Russian Federation.

Elena Molochkina (E)

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Kosygin str 4, Moscow, 119334, Russian Federation.

Patrick Masson (P)

Kazan Federal University, Neuropharmacology Laboratory, Kremlevskaya str 18, 480002, Kazan, Russian Federation. Electronic address: pym.masson@free.fr.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Acetylcholinesterase › α-tocopherol, a slow-binding inhibitor of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Anticholinestérasiques › α-tocopherol, a slow-binding inhibitor of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › α-tocopherol, a slow-binding inhibitor of...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › α-tocopherol, a slow-binding inhibitor of...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › α-tocopherol, a slow-binding inhibitor of...
questionsmedicales.fr › Métabolisme › Phosphorylation › α-tocopherol, a slow-binding inhibitor of...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › α-tocopherol, a slow-binding inhibitor of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › Vitamine E › Tocophérols › alpha-Tocophérol › α-tocopherol, a slow-binding inhibitor of...