Perfusion parameters derived from MRI for preoperative prediction of IDH mutation and MGMT promoter methylation status in glioblastomas.
Brain Neoplasms
/ diagnostic imaging
DNA Modification Methylases
/ genetics
DNA Repair Enzymes
/ genetics
Diffusion Magnetic Resonance Imaging
Glioblastoma
/ diagnostic imaging
Humans
Isocitrate Dehydrogenase
/ genetics
Magnetic Resonance Imaging
Methylation
Mutation
Perfusion
Retrospective Studies
Tumor Suppressor Proteins
/ genetics
Dynamic susceptibility contrast (DSC)
Glioblastoma
IDH mutation
Intravoxel incoherent motion (IVIM)
MGMT promoter methylation
Journal
Magnetic resonance imaging
ISSN: 1873-5894
Titre abrégé: Magn Reson Imaging
Pays: Netherlands
ID NLM: 8214883
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
07
04
2021
revised:
14
08
2021
accepted:
05
09
2021
pubmed:
11
9
2021
medline:
21
10
2021
entrez:
10
9
2021
Statut:
ppublish
Résumé
To investigate the feasibility for preoperative prediction of IDH mutation and MGMT promoter methylation status in glioblastomas(GBMs) by intravoxel incoherent motion(IVIM) and dynamic susceptibility contrast(DSC). Preoperative IVIM and DSC images of 71 patients(IDH mutation:45, IDH wildtype: 26; MGMT methylation: 31, MGMT unmethylation:40) with glioblastomas were analyzed retrospectively. Perfusion parameters including microcirculation perfusion coefficient(D*), perfusion fraction(f), cerebral blood volume(CBV) and cerebral blood flow(CBF) were measured. Corrected perfusion parameters containing corrected perfusion coefficient(ADC The IVIM parameters showed merely moderate correlations with CBV and showed no correlation with CBF. IDH mutation GBMs showed lower D*, ADC IDH mutation and MGMT promoter methylation status in GBMs can be assessed effectively by IVIM and DSC. Besides, D* was the independent predictor of IDH mutation status.
Identifiants
pubmed: 34506909
pii: S0730-725X(21)00146-6
doi: 10.1016/j.mri.2021.09.005
pii:
doi:
Substances chimiques
Tumor Suppressor Proteins
0
Isocitrate Dehydrogenase
EC 1.1.1.41
IDH1 protein, human
EC 1.1.1.42.
DNA Modification Methylases
EC 2.1.1.-
MGMT protein, human
EC 2.1.1.63
DNA Repair Enzymes
EC 6.5.1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
189-195Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.