TNF-α-mediated m
Adaptor Proteins, Signal Transducing
/ genetics
Adenosine
/ analogs & derivatives
Animals
Biopsy
Bone Marrow
/ pathology
Case-Control Studies
Cell Differentiation
/ genetics
Cell Movement
/ genetics
DNA Methylation
Disease Models, Animal
Epigenesis, Genetic
Female
HEK293 Cells
Healthy Volunteers
Humans
Male
Mesenchymal Stem Cells
/ pathology
Mice
Osteogenesis
/ genetics
Primary Cell Culture
Spondylitis, Ankylosing
/ chemically induced
Tumor Necrosis Factor-alpha
/ metabolism
X-Ray Microtomography
beta-Glucans
/ administration & dosage
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
10 09 2021
10 09 2021
Historique:
received:
01
09
2020
accepted:
12
08
2021
entrez:
11
9
2021
pubmed:
12
9
2021
medline:
15
10
2021
Statut:
epublish
Résumé
Ankylosing spondylitis (AS) is a type of rheumatic disease characterized by chronic inflammation and pathological osteogenesis in the entheses. Previously, we demonstrated that enhanced osteogenic differentiation of MSC from AS patients (AS-MSC) resulted in pathological osteogenesis, and that during the enhanced osteogenic differentiation course, AS-MSC induced TNF-α-mediated local inflammation. However, whether TNF-α in turn affects AS-MSC remains unknown. Herein, we further demonstrate that a high-concentration TNF-α treatment triggers enhanced directional migration of AS-MSC in vitro and in vivo, which enforces AS pathogenesis. Mechanistically, TNF-α leads to increased expression of ELMO1 in AS-MSC, which is mediated by a METTL14 dependent m
Identifiants
pubmed: 34508078
doi: 10.1038/s41467-021-25710-4
pii: 10.1038/s41467-021-25710-4
pmc: PMC8433149
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
ELMO1 protein, human
0
ELMO1 protein, mouse
0
TNF protein, human
0
Tumor Necrosis Factor-alpha
0
beta-Glucans
0
curdlan
6930DL209R
N-methyladenosine
CLE6G00625
Adenosine
K72T3FS567
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5373Informations de copyright
© 2021. The Author(s).
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