GRAND: a database of gene regulatory network models across human conditions.
Journal
Nucleic acids research
ISSN: 1362-4962
Titre abrégé: Nucleic Acids Res
Pays: England
ID NLM: 0411011
Informations de publication
Date de publication:
07 01 2022
07 01 2022
Historique:
accepted:
08
09
2021
revised:
17
08
2021
received:
01
06
2021
pubmed:
12
9
2021
medline:
24
2
2022
entrez:
11
9
2021
Statut:
ppublish
Résumé
Gene regulation plays a fundamental role in shaping tissue identity, function, and response to perturbation. Regulatory processes are controlled by complex networks of interacting elements, including transcription factors, miRNAs and their target genes. The structure of these networks helps to determine phenotypes and can ultimately influence the development of disease or response to therapy. We developed GRAND (https://grand.networkmedicine.org) as a database for computationally-inferred, context-specific gene regulatory network models that can be compared between biological states, or used to predict which drugs produce changes in regulatory network structure. The database includes 12 468 genome-scale networks covering 36 human tissues, 28 cancers, 1378 unperturbed cell lines, as well as 173 013 TF and gene targeting scores for 2858 small molecule-induced cell line perturbation paired with phenotypic information. GRAND allows the networks to be queried using phenotypic information and visualized using a variety of interactive tools. In addition, it includes a web application that matches disease states to potentially therapeutic small molecule drugs using regulatory network properties.
Identifiants
pubmed: 34508353
pii: 6368528
doi: 10.1093/nar/gkab778
pmc: PMC8728257
doi:
Substances chimiques
MicroRNAs
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
D610-D621Subventions
Organisme : NLM NIH HHS
ID : R01 LM008795
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA062924
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA231846
Pays : United States
Organisme : NHLBI NIH HHS
ID : K25 HL140186
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA220523
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA127003
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL132825
Pays : United States
Organisme : NHLBI NIH HHS
ID : K25 HL133599
Pays : United States
Organisme : NIH HHS
ID : R35 CA220523
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG011393
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA236764
Pays : United States
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.
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