Antitumor CD8 T cell responses in glioma patients are effectively suppressed by T follicular regulatory cells.
Adolescent
Adult
Aged
Brain Neoplasms
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
Female
Glioma
/ immunology
Humans
Lymphocytes, Tumor-Infiltrating
/ immunology
Male
Middle Aged
T-Lymphocytes, Helper-Inducer
/ immunology
T-Lymphocytes, Regulatory
/ immunology
Tumor Cells, Cultured
Young Adult
CD8 T cell
Glioma
T follicular regulatory cell
Journal
Experimental cell research
ISSN: 1090-2422
Titre abrégé: Exp Cell Res
Pays: United States
ID NLM: 0373226
Informations de publication
Date de publication:
15 10 2021
15 10 2021
Historique:
received:
05
06
2020
revised:
24
08
2021
accepted:
01
09
2021
pubmed:
12
9
2021
medline:
23
11
2021
entrez:
11
9
2021
Statut:
ppublish
Résumé
Regulatory T (Treg) cells are thought to contribute to tumor pathogenesis by suppressing tumor immunosurveillance and antitumor immunity. T follicular regulatory (Tfr) cells are a recently characterized Treg subset that expresses both the Treg transcription factor (TF) Foxp3 and the T follicular helper (Tfh) TF Bcl-6. The role of Tfr cells in glioma patients remains unclear. In this study, we found that the level of Tfr cells, identified as Foxp3
Identifiants
pubmed: 34508744
pii: S0014-4827(21)00361-X
doi: 10.1016/j.yexcr.2021.112808
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
112808Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.