Schrödinger's T Cells: Molecular Insights Into Stemness and Exhaustion.

Cell Differentiation Epigenesis, Genetic Immunotherapy / methods Neoplasms / immunology Persistent Infection / immunology T-Lymphocytes / physiology
T cell T cell exhaustion T cell stemness epigenetic regulation transcription factor transplantation

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2021
Historique:
received: 15 06 2021
accepted: 11 08 2021
entrez: 13 9 2021
pubmed: 14 9 2021
medline: 12 1 2022
Statut: epublish

Résumé

T cell stemness and exhaustion coexist as two key contrasting phenomena during chronic antigen stimulation, such as infection, transplant, cancer, and autoimmunity. T cell exhaustion refers to the progressive loss of effector function caused by chronic antigen exposure. Exhausted T (T

Identifiants

DOI: 10.3389/fimmu.2021.725618 PMID: 34512656 PMC: PMC8427607
pubmed: 34512656
doi: 10.3389/fimmu.2021.725618
pmc: PMC8427607
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

725618

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI132492
Pays : United States

Informations de copyright

Copyright © 2021 Gonzalez, Zou, Gu and Chen.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Nancy M Gonzalez (NM)

Immunobiology & Transplant Science Center, Department of Surgery, Houston Methodist Research Institute & Institute for Academic Medicine, Houston Methodist Hospital, Houston, TX, United States.
College of Medicine, Texas A&M Health Science Center, College Station, TX, United States.

Dawei Zou (D)

Immunobiology & Transplant Science Center, Department of Surgery, Houston Methodist Research Institute & Institute for Academic Medicine, Houston Methodist Hospital, Houston, TX, United States.

Andy Gu (A)

Immunobiology & Transplant Science Center, Department of Surgery, Houston Methodist Research Institute & Institute for Academic Medicine, Houston Methodist Hospital, Houston, TX, United States.

Wenhao Chen (W)

Immunobiology & Transplant Science Center, Department of Surgery, Houston Methodist Research Institute & Institute for Academic Medicine, Houston Methodist Hospital, Houston, TX, United States.
Department of Surgery, Weill Cornell Medicine, Cornell University, New York, NY, United States.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Schrödinger's T Cells: Molecular Insights Into...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Schrödinger's T Cells: Molecular Insights Into...
questionsmedicales.fr › Thérapeutique › Biothérapie › Immunothérapie › Schrödinger's T Cells: Molecular Insights Into...
questionsmedicales.fr › Tumeurs › Schrödinger's T Cells: Molecular Insights Into...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Infection persistante › Schrödinger's T Cells: Molecular Insights Into...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Schrödinger's T Cells: Molecular Insights Into...