Impact of Toll-Like Receptor-Specific Agonists on the Host Immune Response to the
CpG
F1-V antigen
Yersinia pestis
immune response
mice
plague
toll-like receptors
vaccine
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
16
06
2021
accepted:
03
08
2021
entrez:
13
9
2021
pubmed:
14
9
2021
medline:
12
1
2022
Statut:
epublish
Résumé
Relatively recent advances in plague vaccinology have produced the recombinant fusion protein F1-V plague vaccine. This vaccine has been shown to readily protect mice from both bubonic and pneumonic plague. The protection afforded by this vaccine is solely based upon the immune response elicited by the F1 or V epitopes expressed on the F1-V fusion protein. Accordingly, questions remain surrounding its efficacy against infection with non-encapsulated (F1-negative) strains. In an attempt to further optimize the F1-V elicited immune response and address efficacy concerns, we examined the inclusion of multiple toll-like receptor agonists into vaccine regimens. We examined the resulting immune responses and also any protection afforded to mice that were exposed to aerosolized
Identifiants
pubmed: 34512658
doi: 10.3389/fimmu.2021.726416
pmc: PMC8430260
doi:
Substances chimiques
Adjuvants, Immunologic
0
Antigens, Bacterial
0
Plague Vaccine
0
Toll-Like Receptors
0
Vaccines, Synthetic
0
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
726416Informations de copyright
Copyright © 2021 Biryukov, Dankmeyer, Shamsuddin, Velez, Rill, Rosario-Acevedo, Klimko, Shoe, Hunter, Ward, Cazares, Fetterer, Bozue, Worsham, Cote and Amemiya.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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