Feminising hormone therapy reduces testicular ACE-2 receptor expression: Implications for treatment or prevention of COVID-19 infection in men.
ACE-2
COVID-19
fertility
oestrogen
progesterone
testicle
transgender
Journal
Andrologia
ISSN: 1439-0272
Titre abrégé: Andrologia
Pays: Germany
ID NLM: 0423506
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
revised:
22
06
2021
received:
05
05
2021
accepted:
24
06
2021
pubmed:
14
9
2021
medline:
4
11
2021
entrez:
13
9
2021
Statut:
ppublish
Résumé
It has been proposed that men hospitalised with COVID-19 be treated with oestrogen or progesterone to improve COVID-19 outcomes. Transgender women (male-to-female) are routinely treated with oestrogen or oestrogen +progesterone for feminisation which provides a model for the effect of feminising hormones on testicular tissue. Our goal was to analyse differences in ACE-2 expression in testicles of trans-women taking oestrogen or oestrogen +progesterone. Orchiectomy specimens were collected from trans-women undergoing gender-affirming surgery, who were taking oestrogen or oestrogen+progesterone preoperatively. For controls, we used benign orchiectomy specimens from cis-gender men. All specimens were stained with H&E, Trichrome (fibrosis), insulin-like 3 antibody (Leydig cell) and ACE-2 IHC. Cells per high-powered field were counted by cell type (Leydig, Sertoli and Germ). Stain intensity was rated on a 0-2 scale. On immunohistochemistry staining for Leydig cells and ACE-2 staining, the oestrogen+progesterone cohort had fewer Leydig cells compared with controls. The oestrogen+progesterone cohort also had greater degree of tissue fibrosis compared with controls and the oestrogen cohort. This work supports the hopeful possibility that a short course of progesterone (or oestrogen+progesterone) could downregulate ACE-2 to protect men from COVID-19 infection.
Identifiants
pubmed: 34514615
doi: 10.1111/and.14186
pmc: PMC8646357
doi:
Substances chimiques
Estrogens
0
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14186Subventions
Organisme : NINDS NIH HHS
ID : K02 NS046468
Pays : United States
Organisme : NIH HHS
ID : K26 OD010945
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS095894
Pays : United States
Informations de copyright
© 2021 Wiley-VCH GmbH.
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