Ameliorative Effects of Oleuropein on Lipopolysaccharide-Induced Acute Lung Injury Model in Rats.
Acute Lung Injury
/ chemically induced
Animals
Anti-Inflammatory Agents
/ pharmacology
Antioxidants
/ pharmacology
Cytokines
/ metabolism
Disease Models, Animal
Inflammation Mediators
/ metabolism
Iridoid Glucosides
/ pharmacology
Lipopolysaccharides
Lung
/ drug effects
Male
Neutrophil Infiltration
/ drug effects
Oxidative Stress
/ drug effects
Rats, Wistar
lipopolysaccharide
lung injury
oleuropein
Journal
Inflammation
ISSN: 1573-2576
Titre abrégé: Inflammation
Pays: United States
ID NLM: 7600105
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
26
01
2021
accepted:
31
05
2021
revised:
24
05
2021
pubmed:
14
9
2021
medline:
18
3
2022
entrez:
13
9
2021
Statut:
ppublish
Résumé
Acute lung injury (ALI) is one of the most common causes of death in diseases with septic shock. Oleuropein, one of the important components of olive leaf, has antioxidant and anti-inflammatory effects. The objective of this study was to investigate the effects of oleuropein on lipopolysaccharide (LPS)-induced ALI in rats. Oleuropein was administered to rats at a dose of 200 mg/kg for 20 days and LPS was given through intratracheal administration to induce ALI. The study was terminated after 12 h. The results showed that in the group treated with oleuropein, inflammatory cytokines and oxidative stress decreased in serum, bronchoalveolar lavage fluid (BALF), and lung tissue, and there were significant improvements in the picture of acute interstitial pneumonia (AIP) caused by LPS in histopathological examination. Based on the findings of the present study, oleuropein showed protective effects against LPS-induced ALI.
Identifiants
pubmed: 34515957
doi: 10.1007/s10753-021-01496-x
pii: 10.1007/s10753-021-01496-x
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Antioxidants
0
Cytokines
0
Inflammation Mediators
0
Iridoid Glucosides
0
Lipopolysaccharides
0
oleuropein
2O4553545L
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2246-2259Subventions
Organisme : Mustafa Kemal Üniversitesi
ID : 20.M.020
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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