Evolution of Multidrug Resistance in Plasmodium falciparum: a Longitudinal Study of Genetic Resistance Markers in the Greater Mekong Subregion.


Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
17 11 2021
Historique:
pubmed: 14 9 2021
medline: 15 12 2021
entrez: 13 9 2021
Statut: ppublish

Résumé

Increasing resistance in Plasmodium falciparum to artemisinins and their artemisinin combination therapy (ACT) partner drugs jeopardizes effective antimalarial treatment. Resistance is worst in the Greater Mekong subregion. Monitoring genetic markers of resistance can help to guide antimalarial therapy. Markers of resistance to artemisinins (

Identifiants

pubmed: 34516247
doi: 10.1128/AAC.01121-21
pmc: PMC8597770
doi:

Substances chimiques

Antimalarials 0
Genetic Markers 0
Multidrug Resistance-Associated Proteins 0
Protozoan Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0112121

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome
ID : 101148/Z/13/Z
Organisme : Wellcome Trust
ID : 106698/B/14/Z
Pays : United Kingdom

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Auteurs

Mallika Imwong (M)

Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.

Kanokon Suwannasin (K)

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.

Suttipat Srisutham (S)

Department of Clinical Microscopy, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand.

Ranitha Vongpromek (R)

Worldwide Antimalarial Resistance Network, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.

Cholrawee Promnarate (C)

Worldwide Antimalarial Resistance Network, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.

Aungkana Saejeng (A)

Division of Vector-Borne Diseases, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand.

Aung Pyae Phyo (AP)

Myanmar Oxford Clinical Research Unit, Yangon, Myanmar.

Stephane Proux (S)

Shoklo Malaria Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Mae Sot, Thailand.

Tiengkham Pongvongsa (T)

Savannakhet Provincial Health Department, Savannakhet, Lao People's Democratic Republic.

Nguon Chea (N)

National Center for Parasitology, Entomology, and Malaria Control, Phnom Penh, Cambodia.

Olivo Miotto (O)

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Wellcome Sanger Institute, Hinxton, United Kingdom.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

Rupam Tripura (R)

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

Chau Nguyen Hoang (C)

Oxford University Clinical Research Unitgrid.412433.3, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.

Lek Dysoley (L)

National Center for Parasitology, Entomology, and Malaria Control, Phnom Penh, Cambodia.

Nghia Ho Dang Trung (N)

Oxford University Clinical Research Unitgrid.412433.3, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.

Thomas J Peto (TJ)

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

James J Callery (JJ)

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.

Rob W van der Pluijm (RW)

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.

Chanaki Amaratunga (C)

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

Mavuto Mukaka (M)

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

Lorenz von Seidlein (L)

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

Mayfong Mayxay (M)

Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Institute of Research and Education Development, University of Health Sciences, Ministry of Health, Vientiane, Lao People's Democratic Republic.
Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospitalgrid.416302.2, Vientiane, Lao People's Democratic Republic.

Nguyen Thanh Thuy-Nhien (NT)

Oxford University Clinical Research Unitgrid.412433.3, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.

Paul N Newton (PN)

Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

Nicholas P J Day (NPJ)

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

Elizabeth A Ashley (EA)

Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospitalgrid.416302.2, Vientiane, Lao People's Democratic Republic.

Francois H Nosten (FH)

Shoklo Malaria Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Mae Sot, Thailand.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

Frank M Smithuis (FM)

Myanmar Oxford Clinical Research Unit, Yangon, Myanmar.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

Mehul Dhorda (M)

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Department of Clinical Microscopy, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

Nicholas J White (NJ)

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

Arjen M Dondorp (AM)

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol Universitygrid.10223.32, Bangkok, Thailand.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

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Classifications MeSH