Virus-induced senescence is a driver and therapeutic target in COVID-19.

Aniline Compounds / pharmacology Animals COVID-19 / complications Cell Line Cellular Senescence / drug effects Cricetinae Dasatinib / pharmacology Disease Models, Animal Female Humans Male Mice Molecular Targeted Therapy Quercetin / pharmacology SARS-CoV-2 / drug effects Sulfonamides / pharmacology Thrombosis / complications COVID-19 Drug Treatment

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
11 2021
Historique:
received: 10 01 2021
accepted: 03 09 2021
pubmed: 14 9 2021
medline: 23 11 2021
entrez: 13 9 2021
Statut: ppublish

Résumé

Derailed cytokine and immune cell networks account for the organ damage and the clinical severity of COVID-19 (refs.

Identifiants

DOI: 10.1038/s41586-021-03995-1 PMID: 34517409
pubmed: 34517409
doi: 10.1038/s41586-021-03995-1
pii: 10.1038/s41586-021-03995-1
doi:

Substances chimiques

Aniline Compounds 0
Sulfonamides 0
Quercetin 9IKM0I5T1E
Dasatinib RBZ1571X5H
navitoclax XKJ5VVK2WD

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

283-289

Subventions

Organisme : Wellcome Trust
ID : FC001134
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : U19 AI142733
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI135972
Pays : United States

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Soyoung Lee (S)

Medical Department of Hematology, Oncology and Tumor Immunology, Molekulares Krebsforschungszentrum (MKFZ), Charité - Universitätsmedizin, Berlin, Germany.
Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium), Partner Site Berlin, Berlin, Germany.
ORCID: 0000-0002-4614-2931

Yong Yu (Y)

Medical Faculty, Johannes Kepler University, Linz, Austria.

Jakob Trimpert (J)

Institute of Virology, Freie Universität Berlin, Berlin, Germany.
ORCID: 0000-0003-1616-0810

Fahad Benthani (F)

Medical Faculty, Johannes Kepler University, Linz, Austria.
ORCID: 0000-0002-3283-307X

Mario Mairhofer (M)

Medical Faculty, Johannes Kepler University, Linz, Austria.

Paulina Richter-Pechanska (P)

Medical Department of Hematology, Oncology and Tumor Immunology, Molekulares Krebsforschungszentrum (MKFZ), Charité - Universitätsmedizin, Berlin, Germany.

Emanuel Wyler (E)

Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
ORCID: 0000-0002-9884-1806

Dimitri Belenki (D)

Medical Department of Hematology, Oncology and Tumor Immunology, Molekulares Krebsforschungszentrum (MKFZ), Charité - Universitätsmedizin, Berlin, Germany.
Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
ORCID: 0000-0002-9004-9849

Sabine Kaltenbrunner (S)

Medical Faculty, Johannes Kepler University, Linz, Austria.

Maria Pammer (M)

Medical Faculty, Johannes Kepler University, Linz, Austria.

Lea Kausche (L)

Medical Department of Hematology, Oncology and Tumor Immunology, Molekulares Krebsforschungszentrum (MKFZ), Charité - Universitätsmedizin, Berlin, Germany.
Department of Hematology and Oncology, Kepler University Hospital, Linz, Austria.

Theresa C Firsching (TC)

Institute of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany.
ORCID: 0000-0003-1378-4951

Kristina Dietert (K)

Institute of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany.
Veterinary Centre for Resistance Research, Freie Universität Berlin, Berlin, Germany.

Michael Schotsaert (M)

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0003-3156-3132

Carles Martínez-Romero (C)

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0001-8888-7715

Gagandeep Singh (G)

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0003-3260-2631

Séverine Kunz (S)

Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
ORCID: 0000-0002-0131-3506

Daniela Niemeyer (D)

Institute of Virology, German Center for Infection Research (DZIF), Charité-Universitätsmedizin,, Berlin, Germany.
ORCID: 0000-0002-1897-6365

Riad Ghanem (R)

Department of Hematology and Oncology, Kepler University Hospital, Linz, Austria.

Helmut J F Salzer (HJF)

Department of Pulmonology, Kepler University Hospital, Linz, Austria.

Christian Paar (C)

Laboratory Medicine, Kepler University Hospital, Linz, Austria.

Michael Mülleder (M)

Core Facility - High-Throughput Mass Spectrometry and Department of Biochemistry, Charité - Universitätsmedizin, Berlin, Germany.

Melissa Uccellini (M)

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Regeneron Pharmaceuticals, New York, NY, USA.

Edward G Michaelis (EG)

Institute of Pathology, Charité - Universitätsmedizin, Berlin, Germany.

Amjad Khan (A)

Department of Chemistry, University of Oxford, Oxford, UK.

Andrea Lau (A)

Medical Department of Hematology, Oncology and Tumor Immunology, Molekulares Krebsforschungszentrum (MKFZ), Charité - Universitätsmedizin, Berlin, Germany.

Martin Schönlein (M)

Medical Department of Hematology, Oncology and Tumor Immunology, Molekulares Krebsforschungszentrum (MKFZ), Charité - Universitätsmedizin, Berlin, Germany.
Department of Oncology, Hematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Anna Habringer (A)

Laboratory Medicine, Kepler University Hospital, Linz, Austria.

Josef Tomasits (J)

Laboratory Medicine, Kepler University Hospital, Linz, Austria.

Julia M Adler (JM)

Institute of Virology, Freie Universität Berlin, Berlin, Germany.

Susanne Kimeswenger (S)

Medical Faculty, Johannes Kepler University, Linz, Austria.
ORCID: 0000-0002-0443-8558

Achim D Gruber (AD)

Institute of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany.
ORCID: 0000-0002-4502-0393

Wolfram Hoetzenecker (W)

Medical Faculty, Johannes Kepler University, Linz, Austria.
Department of Dermatology, Kepler University Hospital, Linz, Austria.

Herta Steinkellner (H)

Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Vienna, Austria.

Bettina Purfürst (B)

Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.

Reinhard Motz (R)

Institute of Pathology, Kepler University Hospital, Linz, Austria.

Francesco Di Pierro (F)

Scientific and Research Department, Velleja Research, Milan, Italy.
Digestive Endoscopy, Fondazione Poliambulanza, Brescia, Italy.

Bernd Lamprecht (B)

Medical Faculty, Johannes Kepler University, Linz, Austria.
Department of Pulmonology, Kepler University Hospital, Linz, Austria.
ORCID: 0000-0003-3365-3449

Nikolaus Osterrieder (N)

Institute of Virology, Freie Universität Berlin, Berlin, Germany.
Department of Infectious Diseases and Public Health, City University of Hong Kong, Kowloon Tong, Hong Kong.

Markus Landthaler (M)

Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
ORCID: 0000-0002-1075-8734

Christian Drosten (C)

Institute of Virology, German Center for Infection Research (DZIF), Charité-Universitätsmedizin,, Berlin, Germany.
ORCID: 0000-0001-7923-0519

Adolfo García-Sastre (A)

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-6551-1827

Rupert Langer (R)

Medical Faculty, Johannes Kepler University, Linz, Austria.
Institute of Pathology, Kepler University Hospital, Linz, Austria.

Markus Ralser (M)

Core Facility - High-Throughput Mass Spectrometry and Department of Biochemistry, Charité - Universitätsmedizin, Berlin, Germany.
The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, UK.

Roland Eils (R)

Center for Digital Health, Charité - Universitätsmedizin and Berlin Institute of Health (BIH), Berlin, Germany.
ORCID: 0000-0002-0034-4036

Maurice Reimann (M)

Medical Department of Hematology, Oncology and Tumor Immunology, Molekulares Krebsforschungszentrum (MKFZ), Charité - Universitätsmedizin, Berlin, Germany.

Dorothy N Y Fan (DNY)

Medical Department of Hematology, Oncology and Tumor Immunology, Molekulares Krebsforschungszentrum (MKFZ), Charité - Universitätsmedizin, Berlin, Germany.
Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium), Partner Site Berlin, Berlin, Germany.

Clemens A Schmitt (CA)

Medical Department of Hematology, Oncology and Tumor Immunology, Molekulares Krebsforschungszentrum (MKFZ), Charité - Universitätsmedizin, Berlin, Germany. clemens.schmitt@charite.de.
Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany. clemens.schmitt@charite.de.
Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium), Partner Site Berlin, Berlin, Germany. clemens.schmitt@charite.de.
Medical Faculty, Johannes Kepler University, Linz, Austria. clemens.schmitt@charite.de.
Department of Hematology and Oncology, Kepler University Hospital, Linz, Austria. clemens.schmitt@charite.de.
ORCID: 0000-0002-4731-2226

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Amines › Dérivés de l'aniline › Virus-induced senescence is a driver and...
questionsmedicales.fr › Eucaryotes › Animaux › Virus-induced senescence is a driver and...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Virus-induced senescence is a driver and...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Virus-induced senescence is a driver and...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Vieillissement de la cellule › Virus-induced senescence is a driver and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Cricetinae › Virus-induced senescence is a driver and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Dasatinib › Virus-induced senescence is a driver and...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Virus-induced senescence is a driver and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Virus-induced senescence is a driver and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Virus-induced senescence is a driver and...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Thérapie moléculaire ciblée › Virus-induced senescence is a driver and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Flavonols › Quercétine › Virus-induced senescence is a driver and...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Virus-induced senescence is a driver and...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfones › Sulfonamides › Virus-induced senescence is a driver and...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Embolie et thrombose › Thrombose › Virus-induced senescence is a driver and...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Traitements médicamenteux de la COVID-19 › Virus-induced senescence is a driver and...