Glycogen Synthase Kinase 3 Regulates the Genesis of Displaced Retinal Ganglion Cells3.

Animals Axons Glycogen Synthase Kinase 3 / genetics Mice Retina Retinal Ganglion Cells
cell death displaced ganglion cells glycogen synthase kinase 3 medial terminal nucleus post-translational modifications retinal development

Journal

eNeuro
ISSN: 2373-2822
Titre abrégé: eNeuro
Pays: United States
ID NLM: 101647362

Informations de publication

Date de publication:
Historique:
received: 19 04 2021
revised: 19 08 2021
accepted: 02 09 2021
pubmed: 15 9 2021
medline: 21 10 2021
entrez: 14 9 2021
Statut: epublish

Résumé

Glycogen synthase kinase 3 (GSK3) proteins (GSK3α and GSK3β) are key mediators of signaling pathways, with crucial roles in coordinating fundamental biological processes during neural development. Here we show that the complete loss of GSK3 signaling in mouse retinal progenitors leads to microphthalmia with broad morphologic defects. A single wild-type allele of either

Identifiants

DOI: 10.1523/ENEURO.0171-21.2021 PMID: 34518365 PMC: PMC8496207
pubmed: 34518365
pii: ENEURO.0171-21.2021
doi: 10.1523/ENEURO.0171-21.2021
pmc: PMC8496207
pii:
doi:

Substances chimiques

Glycogen Synthase Kinase 3 EC 2.7.11.26

Types de publication

Journal Article Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2021 Kisseleff et al.

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Auteurs

Elena Kisseleff (E)

Paris-Saclay Institute of Neuroscience, CERTO-Retina France, CNRS, Université Paris-Saclay, 91400, Saclay, France.

Robin J Vigouroux (RJ)

UPMC Université Paris 06, INSERM, CNRS, Institut de la Vision, Sorbonne Universités, 75012 Paris, France.

Catherine Hottin (C)

Paris-Saclay Institute of Neuroscience, CERTO-Retina France, CNRS, Université Paris-Saclay, 91400, Saclay, France.

Sophie Lourdel (S)

Paris-Saclay Institute of Neuroscience, CERTO-Retina France, CNRS, Université Paris-Saclay, 91400, Saclay, France.

Leah Thomas (L)

Paris-Saclay Institute of Neuroscience, CERTO-Retina France, CNRS, Université Paris-Saclay, 91400, Saclay, France.

Parth Shah (P)

Neurobiology-Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892.

Alain Chédotal (A)

UPMC Université Paris 06, INSERM, CNRS, Institut de la Vision, Sorbonne Universités, 75012 Paris, France.

Muriel Perron (M)

Paris-Saclay Institute of Neuroscience, CERTO-Retina France, CNRS, Université Paris-Saclay, 91400, Saclay, France jerome.roger@universite-paris-saclay.fr swaroopa@nei.nih.gov muriel.perron@universite-paris-saclay.fr.
ORCID: 0000-0002-1558-8236

Anand Swaroop (A)

Neurobiology-Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 jerome.roger@universite-paris-saclay.fr swaroopa@nei.nih.gov muriel.perron@universite-paris-saclay.fr.
ORCID: 0000-0002-1975-1141

Jerome E Roger (JE)

Paris-Saclay Institute of Neuroscience, CERTO-Retina France, CNRS, Université Paris-Saclay, 91400, Saclay, France jerome.roger@universite-paris-saclay.fr swaroopa@nei.nih.gov muriel.perron@universite-paris-saclay.fr.
Neurobiology-Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892.
ORCID: 0000-0002-5061-230X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Glycogen Synthase Kinase 3 Regulates the...
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Axones › Glycogen Synthase Kinase 3 Regulates the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Proline-directed protein kinases › Glycogen Synthase Kinase 3 › Glycogen Synthase Kinase 3 Regulates the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Glycogen Synthase Kinase 3 Regulates the...
questionsmedicales.fr › Organes des sens › Oeil › Rétine › Glycogen Synthase Kinase 3 Regulates the...
questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Neurones rétiniens › Cellules ganglionnaires rétiniennes › Glycogen Synthase Kinase 3 Regulates the...