Distinct population code for movement kinematics and changes of ongoing movements in human subthalamic nucleus.
basal ganglia
cognitive control
electrophysiology
human
neuroscience
subthalamic nucleus
systems neuroscience
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
14 09 2021
14 09 2021
Historique:
received:
13
11
2020
accepted:
14
09
2021
pubmed:
15
9
2021
medline:
23
11
2021
entrez:
14
9
2021
Statut:
epublish
Résumé
The subthalamic nucleus (STN) is theorized to globally suppress movement through connections with downstream basal ganglia structures. Current theories are supported by increased STN activity when subjects withhold an uninitiated action plan, but a critical test of these theories requires studying STN responses when an ongoing action is replaced with an alternative. We perform this test in subjects with Parkinson's disease using an extended reaching task where the movement trajectory changes mid-action. We show that STN activity decreases during action switches, contrary to prevalent theories. Furthermore, beta oscillations in the STN local field potential, which are associated with movement inhibition, do not show increased power or spiking entrainment during switches. We report an inhomogeneous population neural code in STN, with one sub-population encoding movement kinematics and direction and another encoding unexpected action switches. We suggest an elaborate neural code in STN that contributes to planning actions and changing the plans.
Identifiants
pubmed: 34519273
doi: 10.7554/eLife.64893
pii: 64893
pmc: PMC8500714
doi:
pii:
Banques de données
Dryad
['10.5061/dryad.2jm63xsq2']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIMH NIH HHS
ID : R01 MH109180
Pays : United States
Informations de copyright
© 2021, London et al.
Déclaration de conflit d'intérêts
DL, AF, KK, MS, MP, AM, RK No competing interests declared
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