Exocrine pancreatic insufficiency related fat malabsorption and its association with autonomic neuropathy in Asian Indians with type 2 diabetes mellitus.
Adult
Aged
Biomarkers
/ blood
Blood Glucose
/ analysis
Case-Control Studies
Cross-Sectional Studies
Diabetes Mellitus, Type 2
/ physiopathology
Diabetic Neuropathies
/ etiology
Dietary Fats
/ administration & dosage
Exocrine Pancreatic Insufficiency
/ complications
Female
Follow-Up Studies
Humans
Malabsorption Syndromes
/ complications
Male
Middle Aged
Prognosis
72 h fecal Fat assay
Asian indians
Autonomic dysfunction
Exocrine pancreatic insufficiency
Fat malabsorption
Type 2 diabetes mellitus
Journal
Diabetes & metabolic syndrome
ISSN: 1878-0334
Titre abrégé: Diabetes Metab Syndr
Pays: Netherlands
ID NLM: 101462250
Informations de publication
Date de publication:
Historique:
received:
07
06
2021
revised:
31
08
2021
accepted:
02
09
2021
pubmed:
15
9
2021
medline:
27
1
2022
entrez:
14
9
2021
Statut:
ppublish
Résumé
We aimed to estimate the prevalence of exocrine pancreatic insufficiency (EPI) related fat malabsorption & to correlate it with measures of autonomic neuropathy in patients with T2DM from India. Patients with T2DM (cases; n = 118) and normo-glycaemic individuals (controls; n = 82) underwent anthropometry and biochemical evaluation at baseline. The 72-hours fecal fat excretion was estimated by the Van de Kamer's titration method. Autonomic neuropathy was evaluated using an automated analyzer. The prevalence of EPI related fat malabsorption in cases was 45% (n = 53; 72 hours mean fecal fat level = 22.7 ± 5.6 g/day). Dysfunctions in the parasympathetic nervous system (PNS; 86.7%; p < 0.05), sympathetic nervous system (SNS; 92.4%; p < 0.05), and both; PNS + SNS (83.1%; p < 0.05) were significant. Amongst measures of PNS dysfunction, there was a significantly higher percentage of abnormal expiration: inspiration ratio (45.3%) and the 30:15 ratio (84.9%) (p < 0.05) in patients with T2DM and EPI related fat malabsorption. In this cross-sectional cohort of Asian Indian patients with T2DM (n = 118), EPI related fat malabsorption correlates significantly with autonomic dysfunction in patients with T2DM. However, these preliminary data need to confirmed in trials with more robust design.
Sections du résumé
BACKGROUND AND AIMS
OBJECTIVE
We aimed to estimate the prevalence of exocrine pancreatic insufficiency (EPI) related fat malabsorption & to correlate it with measures of autonomic neuropathy in patients with T2DM from India.
METHODS
METHODS
Patients with T2DM (cases; n = 118) and normo-glycaemic individuals (controls; n = 82) underwent anthropometry and biochemical evaluation at baseline. The 72-hours fecal fat excretion was estimated by the Van de Kamer's titration method. Autonomic neuropathy was evaluated using an automated analyzer.
RESULTS
RESULTS
The prevalence of EPI related fat malabsorption in cases was 45% (n = 53; 72 hours mean fecal fat level = 22.7 ± 5.6 g/day). Dysfunctions in the parasympathetic nervous system (PNS; 86.7%; p < 0.05), sympathetic nervous system (SNS; 92.4%; p < 0.05), and both; PNS + SNS (83.1%; p < 0.05) were significant. Amongst measures of PNS dysfunction, there was a significantly higher percentage of abnormal expiration: inspiration ratio (45.3%) and the 30:15 ratio (84.9%) (p < 0.05) in patients with T2DM and EPI related fat malabsorption.
CONCLUSION
CONCLUSIONS
In this cross-sectional cohort of Asian Indian patients with T2DM (n = 118), EPI related fat malabsorption correlates significantly with autonomic dysfunction in patients with T2DM. However, these preliminary data need to confirmed in trials with more robust design.
Identifiants
pubmed: 34520998
pii: S1871-4021(21)00293-9
doi: 10.1016/j.dsx.2021.102273
pii:
doi:
Substances chimiques
Biomarkers
0
Blood Glucose
0
Dietary Fats
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
102273Informations de copyright
Copyright © 2021 Diabetes India. Published by Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no conflicts of interest pertaining to this study.