Attenuation of peripheral serotonin inhibits tumor growth and enhances immune checkpoint blockade therapy in murine tumor models.

Animals Immune Checkpoint Inhibitors Mice Neoplasms / drug therapy Serotonin

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
15 Sep 2021
Historique:
entrez: 15 9 2021
pubmed: 16 9 2021
medline: 3 11 2021
Statut: ppublish

Résumé

Platelet-derived peripheral serotonin has pleiotropic effects on coagulation, metabolism, tissue regeneration, and cancer growth; however, the effect of serotonin on the tumor microenvironment remains understudied. Peripheral serotonin–deficient (

Identifiants

DOI: 10.1126/scitranslmed.abc8188 PMID: 34524861
pubmed: 34524861
doi: 10.1126/scitranslmed.abc8188
doi:

Substances chimiques

Immune Checkpoint Inhibitors 0
Serotonin 333DO1RDJY

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabc8188

Auteurs

Marcel André Schneider (MA)

Laboratory of the Swiss Hepato-Pancreatico-Biliary (HPB) and Transplantation Centre, Department of Surgery, University Hospital and University of Zürich, Raemistrasse 100, CH-8091 Zürich, Switzerland.
ORCID: 0000-0002-6723-8879

Laura Heeb (L)

Laboratory of the Swiss Hepato-Pancreatico-Biliary (HPB) and Transplantation Centre, Department of Surgery, University Hospital and University of Zürich, Raemistrasse 100, CH-8091 Zürich, Switzerland.
ORCID: 0000-0003-3362-5966

Michal Mateusz Beffinger (MM)

Institute of Laboratory Animal Science, University of Zürich, Wagistrasse 12, CH-8952 Schlieren, Switzerland.
ORCID: 0000-0002-6916-7517

Stanislav Pantelyushin (S)

Institute of Laboratory Animal Science, University of Zürich, Wagistrasse 12, CH-8952 Schlieren, Switzerland.
ORCID: 0000-0002-3490-3860

Michael Linecker (M)

Laboratory of the Swiss Hepato-Pancreatico-Biliary (HPB) and Transplantation Centre, Department of Surgery, University Hospital and University of Zürich, Raemistrasse 100, CH-8091 Zürich, Switzerland.
ORCID: 0000-0002-0721-6811

Lilian Roth (L)

Laboratory of the Swiss Hepato-Pancreatico-Biliary (HPB) and Transplantation Centre, Department of Surgery, University Hospital and University of Zürich, Raemistrasse 100, CH-8091 Zürich, Switzerland.
Surgical Oncology Research Laboratory, Department of Surgery, University Hospital and University of Zürich, Raemistrasse 100, CH-8091 Zürich, Switzerland.

Kuno Lehmann (K)

Surgical Oncology Research Laboratory, Department of Surgery, University Hospital and University of Zürich, Raemistrasse 100, CH-8091 Zürich, Switzerland.

Udo Ungethüm (U)

Laboratory of the Swiss Hepato-Pancreatico-Biliary (HPB) and Transplantation Centre, Department of Surgery, University Hospital and University of Zürich, Raemistrasse 100, CH-8091 Zürich, Switzerland.

Sebastian Kobold (S)

Center of Integrated Protein Science Munich (CIPS-M) and Division of Clinical Pharmacology, Department of Medicine IV, Klinikum der Ludwig-Maximilians-Universität München, Lindwurmstrasse 2a, D-80337 Munich, Germany.
German Center for Translational Cancer Research (DKTK), partner site Munich, Pettenkoferstr. 8a, D-80336 Munich, Germany.
ORCID: 0000-0002-5612-4673

Rolf Graf (R)

Laboratory of the Swiss Hepato-Pancreatico-Biliary (HPB) and Transplantation Centre, Department of Surgery, University Hospital and University of Zürich, Raemistrasse 100, CH-8091 Zürich, Switzerland.
ORCID: 0000-0001-7449-7302

Maries van den Broek (M)

Institute of Experimental Immunology, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
ORCID: 0000-0002-9489-3692

Johannes Vom Berg (J)

Institute of Laboratory Animal Science, University of Zürich, Wagistrasse 12, CH-8952 Schlieren, Switzerland.
ORCID: 0000-0002-4086-1564

Anurag Gupta (A)

Laboratory of the Swiss Hepato-Pancreatico-Biliary (HPB) and Transplantation Centre, Department of Surgery, University Hospital and University of Zürich, Raemistrasse 100, CH-8091 Zürich, Switzerland.
ORCID: 0000-0001-6850-3489

Pierre-Alain Clavien (PA)

Laboratory of the Swiss Hepato-Pancreatico-Biliary (HPB) and Transplantation Centre, Department of Surgery, University Hospital and University of Zürich, Raemistrasse 100, CH-8091 Zürich, Switzerland.
ORCID: 0000-0002-9916-7905

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Attenuation of peripheral serotonin inhibits...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Antinéoplasiques immunologiques › Inhibiteurs de points de contrôle immunitaires › Attenuation of peripheral serotonin inhibits...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Attenuation of peripheral serotonin inhibits...
questionsmedicales.fr › Tumeurs › Attenuation of peripheral serotonin inhibits...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Sérotonine › Attenuation of peripheral serotonin inhibits...