Evaluation of Antimicrobial Susceptibility Testing Methods for Burkholderia cenocepacia and Burkholderia multivorans Isolates from Cystic Fibrosis Patients.


Journal

Journal of clinical microbiology
ISSN: 1098-660X
Titre abrégé: J Clin Microbiol
Pays: United States
ID NLM: 7505564

Informations de publication

Date de publication:
18 11 2021
Historique:
pubmed: 16 9 2021
medline: 15 12 2021
entrez: 15 9 2021
Statut: ppublish

Résumé

The Burkholderia cepacia complex (BCC) is known for causing serious lung infections in people with cystic fibrosis (CF). These infections can require lung transplantation, eligibility for which may be guided by antimicrobial susceptibility testing (AST). While the Clinical and Laboratory Standards Institute recommends AST for BCC, the European Committee on Antimicrobial Susceptibility Testing (EUCAST) does not, due to poor method performance and correlation with clinical outcomes. Furthermore, limited data exist on the performance of automated AST methods for BCC. To address these issues, reproducibility and accuracy were evaluated for disk diffusion (DD), broth microdilution (BMD), and MicroScan WalkAway using 50 B. cenocepacia and 50

Identifiants

pubmed: 34524889
doi: 10.1128/JCM.01447-21
pmc: PMC8601252
doi:

Substances chimiques

Anti-Bacterial Agents 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0144721

Subventions

Organisme : NIAID NIH HHS
ID : K22 AI127473
Pays : United States
Organisme : NIAID NIH HHS
ID : K22AI127473
Pays : United States

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Auteurs

Holly K Huse (HK)

Department of Pathology and Laboratory Medicine, Harbor-UCLA Medical Center, Torrance, California, USA.

Mark J Lee (MJ)

Department of Pathology and Clinical Microbiology Laboratory, Duke University School of Medicine, Durham, North Carolina, USA.

Mandy Wootton (M)

Specialist Antimicrobial Chemotherapy Unit, Public Health Wales, University Hospital of Wales, Cardiff, United Kingdom.

Susan E Sharp (SE)

Copan Diagnostics, Murrieta, California, USA.

Maria Traczewski (M)

Clinical Microbiology Institute, Inc., Wilsonville, Oregon, USA.

John J LiPuma (JJ)

Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.

Peter Jorth (P)

Department of Pathology and Laboratory Medicine, Medicine, and Biomedical Sciences, Cedars-Sinai Medical Centergrid.50956.3f, Los Angeles, California, USA.

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