Decidual Inflammation Drives Chemokine-Mediated Immune Infiltration Contributing to Term Labor.
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
15 10 2021
15 10 2021
Historique:
received:
25
05
2021
accepted:
30
07
2021
pubmed:
17
9
2021
medline:
3
11
2021
entrez:
16
9
2021
Statut:
ppublish
Résumé
Infiltration of maternal peripheral leukocytes into the uterine tissues is a critical event occurring before, during, and after term labor (TL). In this article, we investigate the contribution of uterine smooth muscle (myometrium) and pregnant endometrium (decidua) to the inflammatory process during human TL. We hypothesize that labor-related physiological inflammation is orchestrated by uterine-secreted cytokines, which dually activate the uterine vascular endothelium and maternal leukocytes to promote their adhesion and infiltration into the uterus. Using Luminex and ELISA assays, we examine a full range of cytokines (45 proteins) in media conditioned by primary decidual and myometrial cells from TL and term not in labor (TNL) women. The effect of conditioned media on the activation of human uterine microvascular endothelial cells was measured by qPCR and on peripheral leukocytes by flow cytometry. Transendothelial migration of calcein-labeled primary leukocytes toward media was assessed by fluorometry. Stromal decidual cells secrete significantly higher levels of multiple cytokines compared with myometrial cells (
Identifiants
pubmed: 34526377
pii: jimmunol.2100493
doi: 10.4049/jimmunol.2100493
pmc: PMC8742659
mid: NIHMS1747319
doi:
Substances chimiques
Chemokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
2015-2026Subventions
Organisme : NIAID NIH HHS
ID : R01 AI133976
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI145890
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD098713
Pays : United States
Organisme : CIHR
ID : FDN-143262
Pays : Canada
Commentaires et corrections
Type : CommentOn
Informations de copyright
Copyright © 2021 by The American Association of Immunologists, Inc.
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