Typhoid Conjugate Vaccines: Advancing the Research and Public Health Agendas.
Salmonella Typhi
Africa
Asia
TyVAC
typhoid conjugate vaccines
typhoid fever
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
20 12 2021
20 12 2021
Historique:
pubmed:
17
9
2021
medline:
27
1
2022
entrez:
16
9
2021
Statut:
ppublish
Résumé
The disease burden of typhoid fever remains high in endemic areas in Asia and Africa, especially in children. Recent clinical trials conducted by the Typhoid Vaccine Acceleration Consortium show typhoid conjugate vaccine (TCV) to be safe, immunogenic, and efficacious at preventing blood culture-confirmed typhoid fever in African and Asian children. Pakistan, Liberia, and Zimbabwe recently introduced TCV through campaigns and routine childhood immunizations, providing protection for this vulnerable population. It is essential to continue this momentum while simultaneously filling data gaps-including typhoid complications-to inform decision-making on TCV introduction. A multidisciplinary approach including surveillance, water, sanitation, and hygiene investments, and large-scale TCV introduction is needed to decrease the burden and mortality of typhoid fever.
Identifiants
pubmed: 34528085
pii: 6370981
doi: 10.1093/infdis/jiab449
pmc: PMC8687070
doi:
Substances chimiques
Typhoid-Paratyphoid Vaccines
0
Vaccines, Conjugate
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
S781-S787Subventions
Organisme : NIDDK NIH HHS
ID : T32 DK067872
Pays : United States
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.
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