Branched-chain amino acids regulate hyaluronan synthesis and PPARα expression in the skin.

Amino Acids, Branched-Chain
branched-chain amino acid hyaluronan hyaluronan synthase skin

Journal

Bioscience, biotechnology, and biochemistry
ISSN: 1347-6947
Titre abrégé: Biosci Biotechnol Biochem
Pays: England
ID NLM: 9205717

Informations de publication

Date de publication:
21 Oct 2021
Historique:
received: 15 07 2021
accepted: 07 09 2021
pubmed: 17 9 2021
medline: 29 1 2022
entrez: 16 9 2021
Statut: ppublish

Résumé

We examined the effects of deletion of branched-chain α-keto acid dehydrogenase kinase (BDK), a key enzyme in branched-chain amino acid catabolism, on hyaluronan synthesis in mice. The skin levels of hyaluronan and the gene expression levels of hyaluronan synthase (Has)2, Has3, and peroxisome proliferator-activated receptor-α were significantly lower in the BDK-knockout group than in the wild-type group.

Identifiants

DOI: 10.1093/bbb/zbab160 PMID: 34529047
pubmed: 34529047
pii: 6371094
doi: 10.1093/bbb/zbab160
doi:

Substances chimiques

Amino Acids, Branched-Chain 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2292-2294

Informations de copyright

© The Author(s) 2021. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry.

Auteurs

Takumi Yamane (T)

Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture, Setagaya-ku, Tokyo, Japan.

Yasuyuki Kitaura (Y)

Laboratory of Nutritional Biochemistry, Graduate School of Bioagricultural Sciences, Nagoya University, Aichi, Japan.

Ken Iwatsuki (K)

Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture, Setagaya-ku, Tokyo, Japan.

Yoshiharu Shimomura (Y)

Department of Food and Nutritional Sciences, College of Bioscience and Biotechnology, Chubu University, Aichi, Japan.

Yuichi Oishi (Y)

Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture, Setagaya-ku, Tokyo, Japan.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés à chaine ramifiée › Branched-chain amino acids regulate hyaluronan...