DNA methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers.
Adolescent
Adult
Adverse Childhood Experiences
Aggression
Antigens, CD
/ genetics
Armed Conflicts
Cell Adhesion Molecules
/ genetics
Cell Adhesion Molecules, Neuronal
/ genetics
Child
DNA Methylation
Democratic Republic of the Congo
Female
Fetal Proteins
/ genetics
Humans
Implosive Therapy
Microfilament Proteins
/ genetics
Stress Disorders, Post-Traumatic
/ genetics
Sulfurtransferases
/ genetics
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
16 09 2021
16 09 2021
Historique:
received:
07
01
2021
accepted:
02
09
2021
entrez:
17
9
2021
pubmed:
18
9
2021
medline:
15
12
2021
Statut:
epublish
Résumé
The aftermath of traumatization lives on in the neural and epigenetic traces creating a momentum of affliction in the psychological and social realm. Can psychotherapy reorganise these memories through changes in DNA methylation signatures? Using a randomised controlled parallel group design, we examined methylome-wide changes in saliva samples of 84 female former child soldiers from Eastern DR Congo before and six months after Narrative Exposure Therapy. Treatment predicted differentially methylated positions (DMPs) related to ALCAM, RIPOR2, AFAP1 and MOCOS. In addition, treatment associations overlapped at gene level with baseline clinical and social outcomes. Treatment related DMPs are involved in memory formation-the key agent in trauma focused treatments-and enriched for molecular pathways commonly affected by trauma related disorders. Results were partially replicated in an independent sample of 53 female former child soldiers from Northern Uganda. Our results suggest a molecular impact of psychological treatment in women with war-related childhood trauma.Trial registration: Addressing Heightened Levels of Aggression in Traumatized Offenders With Psychotherapeutic Means (ClinicalTrials.gov Identifier: NCT02992561, 14/12/2016).
Identifiants
pubmed: 34531495
doi: 10.1038/s41598-021-98067-9
pii: 10.1038/s41598-021-98067-9
pmc: PMC8445994
doi:
Substances chimiques
AFAP1 protein, human
0
ALCAM protein, human
0
Antigens, CD
0
Cell Adhesion Molecules
0
Cell Adhesion Molecules, Neuronal
0
Fetal Proteins
0
Microfilament Proteins
0
RIPOR2 protein, human
0
MOCOS protein, human
EC 2.8.1.-
Sulfurtransferases
EC 2.8.1.-
Banques de données
ClinicalTrials.gov
['NCT02992561']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18493Informations de copyright
© 2021. The Author(s).
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