Natural Inhibitors against Potential Targets of Cyclooxygenase, Lipoxygenase and Leukotrienes.
COX
LOX
Pain and inflammation mediators
alternative medicine
leukotrienes (LTs)
natural inhibitors
Journal
Combinatorial chemistry & high throughput screening
ISSN: 1875-5402
Titre abrégé: Comb Chem High Throughput Screen
Pays: United Arab Emirates
ID NLM: 9810948
Informations de publication
Date de publication:
2022
2022
Historique:
received:
15
02
2021
revised:
14
07
2021
accepted:
18
07
2021
pubmed:
18
9
2021
medline:
8
11
2022
entrez:
17
9
2021
Statut:
ppublish
Résumé
Cyclooxygenase (COX) and Lipoxygenase (LOX) enzymes catalyze the production of pain mediators like Prostaglandins (PGs) and Leukotrienes (LTs), respectively from arachidonic acid. The COX and LOX enzyme modulators are responsible for the major PGs and LTs mediated complications like asthma, osteoarthritis, rheumatoid arthritis, cancer, Alzheimer's disease, neuropathy and Cardiovascular Syndromes (CVS). Many synthetic Nonsteroidal Anti- Inflammatory Drugs (NSAIDs) used in the treatment have serious side effects like nausea, vomiting, hyperacidity, gastrointestinal ulcers, CVS, etc. Methods: The natural inhibitors of pain mediators have great acceptance worldwide due to fewer side effects on long-term uses. The present review is an extensive study of the advantages of plantbased vs synthetic inhibitors. These natural COX and LOX inhibitors control inflammatory response without causing side-effect-related complicacy. Therefore, the natural COX and LOX inhibitors may be used as alternative medicines for the management of pain and inflammation due to their less toxicity and resistivity.
Sections du résumé
BACKGROUND
Cyclooxygenase (COX) and Lipoxygenase (LOX) enzymes catalyze the production of pain mediators like Prostaglandins (PGs) and Leukotrienes (LTs), respectively from arachidonic acid.
INTRODUCTION
The COX and LOX enzyme modulators are responsible for the major PGs and LTs mediated complications like asthma, osteoarthritis, rheumatoid arthritis, cancer, Alzheimer's disease, neuropathy and Cardiovascular Syndromes (CVS). Many synthetic Nonsteroidal Anti- Inflammatory Drugs (NSAIDs) used in the treatment have serious side effects like nausea, vomiting, hyperacidity, gastrointestinal ulcers, CVS, etc. Methods: The natural inhibitors of pain mediators have great acceptance worldwide due to fewer side effects on long-term uses. The present review is an extensive study of the advantages of plantbased vs synthetic inhibitors.
RESULTS
These natural COX and LOX inhibitors control inflammatory response without causing side-effect-related complicacy.
CONCLUSION
Therefore, the natural COX and LOX inhibitors may be used as alternative medicines for the management of pain and inflammation due to their less toxicity and resistivity.
Identifiants
pubmed: 34533441
pii: CCHTS-EPUB-117998
doi: 10.2174/1386207325666210917111847
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Cyclooxygenase Inhibitors
0
Lipoxygenase Inhibitors
0
Leukotriene Antagonists
0
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2341-2357Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.