Endosomal trafficking and DNA damage checkpoint kinases dictate survival to replication stress by regulating amino acid uptake and protein synthesis.

Autophagy / physiology Beclin-1 / metabolism Cell Cycle Proteins / metabolism DNA Damage / physiology Endosomes / metabolism Phosphorylation Saccharomyces cerevisiae / metabolism Saccharomyces cerevisiae Proteins / metabolism Yeasts
Atg6/Beclin 1 DNA damage response Gcn2 Rad53 TORC1 amino acids endosomal trafficking phosphatydilinositol 3-phosphate replication stress

Journal

Developmental cell
ISSN: 1878-1551
Titre abrégé: Dev Cell
Pays: United States
ID NLM: 101120028

Informations de publication

Date de publication:
27 09 2021
Historique:
received: 04 01 2021
revised: 11 06 2021
accepted: 20 08 2021
pubmed: 18 9 2021
medline: 1 12 2021
entrez: 17 9 2021
Statut: ppublish

Résumé

Atg6

Identifiants

DOI: 10.1016/j.devcel.2021.08.019 PMID: 34534458
pubmed: 34534458
pii: S1534-5807(21)00678-X
doi: 10.1016/j.devcel.2021.08.019
pii:
doi:

Substances chimiques

Beclin-1 0
Cell Cycle Proteins 0
Saccharomyces cerevisiae Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2607-2622.e6

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Arta Ajazi (A)

IFOM, The FIRC Institute of Molecular Oncology, Milan 20139, Italy. Electronic address: arta.ajazi@ifom.eu.

Christopher Bruhn (C)

IFOM, The FIRC Institute of Molecular Oncology, Milan 20139, Italy.

Ghadeer Shubassi (G)

Centre for Probe Development and Commercialization, Hamilton, ON L8S 4L8, Canada.

Chiara Lucca (C)

IFOM, The FIRC Institute of Molecular Oncology, Milan 20139, Italy.

Elisa Ferrari (E)

IFOM, The FIRC Institute of Molecular Oncology, Milan 20139, Italy.

Angela Cattaneo (A)

Cogentech, S.R.L. Benefit Corporation IT, Milan 20139, Italy.

Angela Bachi (A)

IFOM, The FIRC Institute of Molecular Oncology, Milan 20139, Italy.

Nicola Manfrini (N)

INGM-Fondazione Istituto Nazionale Genetica Molecolare "Romeo and Enrica Invernizzi", Milan 20122, Italy; Department of Biosciences, University of Milan, Milan 20133, Italy.

Stefano Biffo (S)

INGM-Fondazione Istituto Nazionale Genetica Molecolare "Romeo and Enrica Invernizzi", Milan 20122, Italy; Department of Biosciences, University of Milan, Milan 20133, Italy.

Emanuele Martini (E)

IFOM, The FIRC Institute of Molecular Oncology, Milan 20139, Italy.

Saverio Minucci (S)

Department of Biosciences, University of Milan, Milan 20133, Italy; Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Milan 20139, Italy.

Claudio Vernieri (C)

IFOM, The FIRC Institute of Molecular Oncology, Milan 20139, Italy; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan 20133, Italy.

Marco Foiani (M)

IFOM, The FIRC Institute of Molecular Oncology, Milan 20139, Italy; Oncology and Haemato-Oncology Department, University of Milan, Milan 20122, Italy. Electronic address: marco.foiani@ifom.eu.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › Endosomal trafficking and DNA damage...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Bécline-1 › Endosomal trafficking and DNA damage...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cycle cellulaire › Endosomal trafficking and DNA damage...
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › Endosomal trafficking and DNA damage...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Vésicules de transport › Endosomes › Endosomal trafficking and DNA damage...
questionsmedicales.fr › Métabolisme › Phosphorylation › Endosomal trafficking and DNA damage...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › Endosomal trafficking and DNA damage...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Protéines de Saccharomyces cerevisiae › Endosomal trafficking and DNA damage...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Endosomal trafficking and DNA damage...