Mothers' cafeteria diet induced sex-specific changes in fat content, metabolic profiles, and inflammation outcomes in rat offspring.
Animals
Animals, Newborn
Body Composition
Diet
Fats
/ analysis
Female
Humans
Inflammation
/ metabolism
Male
Maternal Nutritional Physiological Phenomena
Metabolome
Pregnancy
Prenatal Exposure Delayed Effects
/ metabolism
Prenatal Nutritional Physiological Phenomena
Rats
Rats, Wistar
Sex Characteristics
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
17 09 2021
17 09 2021
Historique:
received:
23
06
2021
accepted:
19
08
2021
entrez:
18
9
2021
pubmed:
19
9
2021
medline:
16
11
2021
Statut:
epublish
Résumé
"Western diet" containing high concentrations of sugar and fat consumed during pregnancy contributes to development of obesity and diabetes type 2 in offspring. To mimic effects of this diet in animals, a cafeteria (CAF) diet is used. We hypothesized that CAF diet given to rats before, and during pregnancy and lactation differently influences fat content, metabolic and inflammation profiles in offspring. Females were exposed to CAF or control diets before pregnancy, during pregnancy and lactation. At postnatal day 25 (PND 25), body composition, fat contents were measured, and blood was collected for assessment of metabolic and inflammation profiles. We have found that CAF diet lead to sex-specific alterations in offspring. At PND25, CAF offspring had: (1) higher percentage of fat content, and were lighter; (2) sex-specific differences in levels of glucose; (3) higher levels of interleukin 6 (IL-6), interleukin-10 (IL-10) and tumor necrosis factor (TNF-α); (4) sex-specific differences in concentration of IL-6 and TNF-α, with an increase in CAF females; (5) higher level of IL-10 in both sexes, with a more pronounced increase in females. We concluded that maternal CAF diet affects fat content, metabolic profiles, and inflammation parameters in offspring. Above effects are sex-specific, with female offspring being more susceptible to the diet.
Identifiants
pubmed: 34535697
doi: 10.1038/s41598-021-97487-x
pii: 10.1038/s41598-021-97487-x
pmc: PMC8448886
doi:
Substances chimiques
Fats
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18573Informations de copyright
© 2021. The Author(s).
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