Evaluation of the sexual health in people living with hemophilia.
hemophilia
patient reported outcome
sexual health
Journal
Haemophilia : the official journal of the World Federation of Hemophilia
ISSN: 1365-2516
Titre abrégé: Haemophilia
Pays: England
ID NLM: 9442916
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
revised:
26
08
2021
received:
18
07
2018
accepted:
31
08
2021
pubmed:
20
9
2021
medline:
11
11
2021
entrez:
19
9
2021
Statut:
ppublish
Résumé
Knowledge about sexual health, difficulty with sexual activity and intimacy (sexual difficulty), in people with hemophilia is little understood. The objectives were to determine the prevalence of sexual difficulty in people living with hemophilia (PWH) compared to people with no bleeding disorders (PWNoBD), and to determine factors associated with it. This was an analysis of the PROBE study. We recruited individuals who had hemophilia A or B (PWH) and PWNoBD who were 18 years old or older. We calculated proportions of participants with sexual difficulty and odds ratios (ORs) adjusted for sex and age with 95% confidence intervals. There were 2007 PWH and 1972 PWNoBD. Mean (standard deviation) age was 41 (15) years in PWH and 42 (13) years in PWNoBD. Sexual difficulty was reported in 302 (15.1%) PWH and 79 (4.0%) PWNoBD. The odds of sexual difficulty were significantly higher in PWH (OR 3.82, 95% CI 2.85, 5.11). Among PWH, older age, experiencing acute or chronic pain in the past 12 months, bleeds within the past two weeks, ≥3 spontaneous joint bleeds (past six months), limitation of range of motion of any joints, and any life- or limb-threatening bleeds in the past 12 months were associated with sexual difficulty. Sexual difficulty is more prevalent in people living with hemophilia and associated with markers of disease severity. Sexual health issues should be incorporated in comprehensive hemophilia care, future research, and hemophilia related health policy.
Sections du résumé
BACKGROUND
BACKGROUND
Knowledge about sexual health, difficulty with sexual activity and intimacy (sexual difficulty), in people with hemophilia is little understood.
OBJECTIVES
OBJECTIVE
The objectives were to determine the prevalence of sexual difficulty in people living with hemophilia (PWH) compared to people with no bleeding disorders (PWNoBD), and to determine factors associated with it.
METHODS
METHODS
This was an analysis of the PROBE study. We recruited individuals who had hemophilia A or B (PWH) and PWNoBD who were 18 years old or older. We calculated proportions of participants with sexual difficulty and odds ratios (ORs) adjusted for sex and age with 95% confidence intervals.
RESULTS
RESULTS
There were 2007 PWH and 1972 PWNoBD. Mean (standard deviation) age was 41 (15) years in PWH and 42 (13) years in PWNoBD. Sexual difficulty was reported in 302 (15.1%) PWH and 79 (4.0%) PWNoBD. The odds of sexual difficulty were significantly higher in PWH (OR 3.82, 95% CI 2.85, 5.11). Among PWH, older age, experiencing acute or chronic pain in the past 12 months, bleeds within the past two weeks, ≥3 spontaneous joint bleeds (past six months), limitation of range of motion of any joints, and any life- or limb-threatening bleeds in the past 12 months were associated with sexual difficulty.
CONCLUSIONS
CONCLUSIONS
Sexual difficulty is more prevalent in people living with hemophilia and associated with markers of disease severity. Sexual health issues should be incorporated in comprehensive hemophilia care, future research, and hemophilia related health policy.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
993-1001Informations de copyright
© 2021 John Wiley & Sons Ltd.
Références
Parish KL. Sexuality and haemophilia: Connections across the life-span. Haemophilia 2002;8:353-359. https://doi.org/10.1046/j.1365-2516.2002.00647.x
Fugh-Berman A, Scialli AR. Testosterone and sexual function. Curr. Opin. Urol. 2017;27:516-518. https://doi.org/10.1097/MOU.0000000000000438
Laumann EO, Nicolosi A, Glasser DB, et al. Sexual problems among women and men aged 40-80 y: Prevalence and correlates identified in the Global Study of Sexual Attitudes and Behaviors. Int J Impot Res 2005;17:39-57. https://doi.org/10.1038/sj.ijir.3901250
Lindau ST, Schumm LP, Laumann EO, Levinson W, O'muircheartaigh CA, Waite LJ A Study of Sexuality and Health among Older Adults in the United States. N Engl J Med 2007;357:762-774. https://doi.org/10.1056/nejmoa067423
Morton L. Sexuality in the Older Adult. Prim. Care - Clin. Off. Pract. 2017;44:429-438. https://doi.org/10.1016/j.pop.2017.04.004
Delamater J, Karraker A. Sexual functioning in older adults. Curr. Psychiatry Rep. 2009;11:6-11. https://doi.org/10.1007/s11920-009-0002-4
Heywood W, Lyons A, Fileborn B, et al. Sexual Satisfaction Among Older Australian Heterosexual Men and Women: Findings from the Sex, Age & Me Study. J Sex Marital Ther 2018;44:295-307. https://doi.org/10.1080/0092623X.2017.1366959
Nusbaum MRH, Hamilton C, Lenahan P. Chronic illness and sexual functioning. Am Fam Physician 2003;67:347-354.
Wändell PE, Brorsson B. Assessing sexual functioning in patients with chronic disorders by using a generic health-related quality of life questionnaire. Qual Life Res 2000;9:1081-1092. https://doi.org/10.1023/A:1016606521786
Hyde Zoë, Flicker L, Hankey GJ, et al. Prevalence of sexual activity and associated factors in men aged 75 to 95 years a cohort study. Ann Intern Med 2010;153:693-702. https://doi.org/10.7326/0003-4819-153-11-201012070-00002
Lindau ST, Gavrilova N. Sex, health, and years of sexually active life gained due to good health: Evidence from two US population based cross sectional surveys of ageing. BMJ 2010;340:580. https://doi.org/10.1136/bmj.c810
Ambler N, De C Williams AC, Hill P, Gunary R, Cratchley G Sexual difficulties of chronic pain patients. Clin J Pain 2001;17:138-145. https://doi.org/10.1097/00002508-200106000-00006
Darby SC, Kan SW, Spooner RJ, et al. Mortality rates, life expectancy, and causes of death in people with hemophilia A or B in the United Kingdom who were not infected with HIV. Blood 2007;110:815-825. https://doi.org/10.1182/blood-2006-10-050435
Franchini M, Mannucci PM. Co-morbidities and quality of life in elderly persons with haemophilia. Br. J. Haematol. 2010;148:522-533. https://doi.org/10.1111/j.1365-2141.2009.08005.x
Rodriguez-Merchan EC. Musculoskeletal complications of hemophilia. HSS J 2010;6:37-42. https://doi.org/10.1007/s11420-009-9140-9
Philipp C. The aging patient with hemophilia: complications, comorbidities, and management issues. Hematology Am Soc Hematol Educ Program 2010;2010:191-6. https://doi.org/10.1182/asheducation-2010.1.191
Patel H, Heathcote EJ. When to treat and the benefits of treating hepatitis C in patients with haemophilia. Haemophilia. 2009;15:20-32. https://doi.org/10.1111/j.1365-2516.2008.01917.x
Aledort LM. HIV and hemophilia. J Thromb Haemost 2007;5:607-608. https://doi.org/10.1111/j.1538-7836.2007.02371.x
Gianotten WL, Heijnen L. Haemophilia, aging and sexuality. Haemophilia. 2009;15:55-62. https://doi.org/10.1111/j.1365-2516.2008.01914.x
Bar-Chama N, Snyder S, Aledort L. Sexual evaluation and treatment of ageing males with haemophilia. Haemophilia 2011;17:875-83. https://doi.org/10.1111/j.1365-2516.2011.02507.x
Dune T. Sexual expression, fulfilment and haemophilia: Reflections from the 16th Australian and New Zealand Haemophilia Conference. Haemophilia. 2012;18. https://doi.org/10.1111/j.1365-2516.2011.02743.x
Tobase P, Mahajan A, Francis D, Leavitt AD, Giermasz A A gap in comprehensive care: Sexual health in men with haemophilia. Haemophilia. 2017;23:e389-91. https://doi.org/10.1111/hae.13276
Mauser-Bunschoten E, Gianotten W, Heinjnen L, et al. Sexuality and Bleeding Disorders. 2014.
Skinner Mw, Chai-Adisaksopha C, Curtis R, et al. The Patient Reported Outcomes, Burdens and Experiences (PROBE) Project: development and evaluation of a questionnaire assessing patient reported outcomes in people with haemophilia. Pilot Feasibility Stud 2018;4:58. https://doi.org/10.1186/s40814-018-0253-0
Chai-Adisaksopha C, Skinner MW, Curtis R, et al. Test-retest properties of the Patient Reported Outcomes, Burdens and Experiences (PROBE) questionnaire and its constituent domains. Haemophilia 2019;25:75-83. https://doi.org/10.1111/hae.13649
Germini F, Debono VB, Page D, et al. Development And Testing Of The Online Probe Survey And The Myprobe App And Integration With The Canadian Bleeding Disorder Registry. In: Haemophilia. 2020. 76-77.
Basson R, Rees P, Wang R, Montejo AL, Incrocci L Sexual function in chronic illness. J Sex Med 2010;7:374-388. https://doi.org/10.1111/j.1743-6109.2009.01621.x
Ponsford J. Sexual changes associated with traumatic brain injury. Neuropsychol Rehabil 2003;13:275-289. https://doi.org/10.1080/09602010244000363
Lundberg PO. Sexual dysfunction in female patients with multiple sclerosis. Disabil Rehabil 1981;3:32-34. https://doi.org/10.3109/03790798109167112
Kimura M, Murata Y, Shimoda K, Robinson RG Sexual dysfunction following stroke. Compr Psychiatry 2001;42:217-222. https://doi.org/10.1053/comp.2001.23141
Mitchell KR, Jones KG, Wellings K, et al. Estimating the Prevalence of Sexual Function Problems: The Impact of Morbidity Criteria. J Sex Res 2016;53:955-967. https://doi.org/10.1080/00224499.2015.1089214
Lewis RW, Fugl-Meyer KS, Corona G, et al. Definitions/epidemiology/risk factors for sexual dysfunction. J Sex Med 2010;7:1598-1607. https://doi.org/10.1111/j.1743-6109.2010.01778.x
Taleporos G, Mccabe MP. Physical disability and sexual esteem. Sex Disabil 2001;19:131-148.
Mccabe MP. Sexual Esteem, Sexual Satisfaction, and Sexual Behavior among People with Physical Disability. Arch Sex Behav 2003;32:359-69. https://doi.org/10.1023/A:1024047100251
Ter Kuile MM, Weijenborg PTM, Spinhoven P. Sexual functioning in women with chronic pelvic pain: The role of anxiety and depression. J Sex Med 2010;7:1901-1910. https://doi.org/10.1111/j.1743-6109.2009.01414.x
Daniell HW. Hypogonadism in men consuming sustained-action oral opioids. J Pain 2002;3:377-384. https://doi.org/10.1054/jpai.2002.126790
Ajo R, Segura A, Inda MM, et al. Opioids Increase Sexual Dysfunction in Patients With Non-Cancer Pain. J Sex Med 2016;13:1377-1386. https://doi.org/10.1016/j.jsxm.2016.07.003
Florence E, Schrooten W, Dreezen C, et al. The Eurosupport Study Group Prevalence and factors associated with sexual dysfunction among HIV-positive women in Europe. In: AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV. AIDS Care 2004. 550-557. https://doi.org/10.1080/09540120410001716333
Luzi K, Guaraldi G, Murri R, et al. Body image is a major determinant of sexual dysfunction in stable HIV-infected women. Antivir Ther 2009;14:85-92.
Rosenbaum TY. Musculoskeletal pain and sexual function in women. J. Sex. Med. 2010;7:645-653. https://doi.org/10.1111/j.1743-6109.2009.01490.x
Arnold E, Lane S, Webert KE, et al. What should men living with haemophilia need to know? The perspectives of Canadian men with haemophilia. Haemophilia 2014;20:219-225. https://doi.org/10.1111/hae.12297
Wylie K, Kenney G. Sexual dysfunction and the ageing male. Maturitas. 2010;65:23-27. https://doi.org/10.1016/j.maturitas.2009.10.018