The evolution of the GALactose utilization pathway in budding yeasts.
fungi
galactose
gene cluster
gene regulation
horizontal gene transfer
polymorphism
regulatory rewiring
Journal
Trends in genetics : TIG
ISSN: 0168-9525
Titre abrégé: Trends Genet
Pays: England
ID NLM: 8507085
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
13
07
2021
revised:
20
08
2021
accepted:
24
08
2021
pubmed:
21
9
2021
medline:
11
3
2022
entrez:
20
9
2021
Statut:
ppublish
Résumé
The Leloir galactose utilization or GAL pathway of budding yeasts, including that of the baker's yeast Saccharomyces cerevisiae and the opportunistic human pathogen Candida albicans, breaks down the sugar galactose for energy and biomass production. The GAL pathway has long served as a model system for understanding how eukaryotic metabolic pathways, including their modes of regulation, evolve. More recently, the physical linkage of the structural genes GAL1, GAL7, and GAL10 in diverse budding yeast genomes has been used as a model for understanding the evolution of gene clustering. In this review, we summarize exciting recent work on three different aspects of this iconic pathway's evolution: gene cluster organization, GAL gene regulation, and the population genetics of the GAL pathway.
Identifiants
pubmed: 34538504
pii: S0168-9525(21)00256-0
doi: 10.1016/j.tig.2021.08.013
pmc: PMC8678326
mid: NIHMS1751472
pii:
doi:
Substances chimiques
Galactose
X2RN3Q8DNE
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
97-106Subventions
Organisme : NIAID NIH HHS
ID : R56 AI146096
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests No interests are declared.
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