RIC3 variants are not associated with Parkinson's disease in large European, Latin American, or East Asian cohorts.
Asian People
Cohort Studies
Europe
Asia, Eastern
Female
Genetic Variation
/ genetics
Genome-Wide Association Study
/ methods
Genotyping Techniques
/ methods
Hispanic or Latino
Humans
Intracellular Signaling Peptides and Proteins
/ genetics
Latin America
Male
Negative Results
Parkinson Disease
/ etiology
White People
Whole Genome Sequencing
Genetics
Parkinson's disease
RIC3
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
01
04
2021
revised:
16
07
2021
accepted:
14
08
2021
pubmed:
21
9
2021
medline:
19
2
2022
entrez:
20
9
2021
Statut:
ppublish
Résumé
Parkinson's disease (PD) is a complex neurodegenerative disorder in which both rare and common genetic variants contribute to disease risk. Multiple genes have been reported to be linked to monogenic PD but these only explain a fraction of the observed familial aggregation. Rare variants in RIC3 have been suggested to be associated with PD in the Indian population. However, replication studies yielded inconsistent results. We further investigate the role of RIC3 variants in PD in European cohorts using individual-level genotyping data from 14,671 PD patients and 17,667 controls, as well as whole-genome sequencing data from 1,615 patients and 961 controls. We also investigated RIC3 using summary statistics from a Latin American cohort of 1,481 individuals, and from a cohort of 31,575 individuals of East Asian ancestry. We did not identify any association between RIC3 and PD in any of the cohorts. However, more studies of rare variants in non-European ancestry populations, in particular South Asian populations, are necessary to further evaluate the world-wide role of RIC3 in PD etiology.
Identifiants
pubmed: 34538707
pii: S0197-4580(21)00263-3
doi: 10.1016/j.neurobiolaging.2021.08.009
pmc: PMC9011339
mid: NIHMS1794037
pii:
doi:
Substances chimiques
Intracellular Signaling Peptides and Proteins
0
RIC3 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
264-268Subventions
Organisme : Intramural NIH HHS
ID : Z99 AG999999
Pays : United States
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
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