Cerebral Blood Flow in the Salience Network of Individuals with Alcohol Use Disorder.
Journal
Alcohol and alcoholism (Oxford, Oxfordshire)
ISSN: 1464-3502
Titre abrégé: Alcohol Alcohol
Pays: England
ID NLM: 8310684
Informations de publication
Date de publication:
09 Jul 2022
09 Jul 2022
Historique:
received:
04
06
2021
revised:
27
07
2021
accepted:
12
08
2021
pubmed:
21
9
2021
medline:
14
7
2022
entrez:
20
9
2021
Statut:
ppublish
Résumé
Magnetic resonance imaging (MRI) studies have identified structural and functional differences in salience network nodes of individuals with alcohol use disorders (AUDs) after chronic exposure to alcohol. However, no studies have investigated cerebral blood flow (CBF) in nontreatment-seeking (NTS) individuals with AUD. In this work, we sought to quantify putative CBF deficits in NTS individuals relative to social drinking (SD) controls and determine if CBF in the salience network is associated with AUD severity. Fifteen NTS (36.5 ± 11.2 years old, 30.0 ± 22.7 drinks/week) and 22 SD (35.6 ± 11.9 years old, 9.1 ± 5.7 drinks/week) underwent pseudocontinuous arterial spin labeling MRI. Compared with social drinkers, NTS individuals had significantly lower CBF in the right and left dorsal anterior insula, and the left ventral anterior and posterior insula. The Alcohol Use Disorder Identification Test (AUDIT) score showed a significant negative relationship with CBF in the bilateral caudal anterior cingulate cortex. In addition, a significant negative correlation was present between number of standard drinks consumed per week and the left frontal opercular CBF. These results provide evidence that insular CBF is negatively associated with heavy drinking, and that severity of alcohol use is related to CBF deficits in key nodes of the salience network. Longitudinal data are needed to understand if disruptions of CBF in the insula and the salience network are a predisposition for or a consequence of chronic AUD.
Identifiants
pubmed: 34541599
pii: 6372093
doi: 10.1093/alcalc/agab062
pmc: PMC9613478
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
445-451Subventions
Organisme : NIAAA NIH HHS
ID : F31 AA025518
Pays : United States
Organisme : NIAAA NIH HHS
ID : R21 AA022650
Pays : United States
Organisme : National Institute of Alcohol Abuse and Alcoholism
ID : R01 AA01835402
Informations de copyright
© The Author(s) 2021. Medical Council on Alcohol and Oxford University Press. All rights reserved.
Références
Addict Biol. 2013 May;18(3):593-604
pubmed: 23240858
Alcohol Clin Exp Res. 2000 Aug;24(8):1214-21
pubmed: 10968660
Addict Behav. 1994 Jan-Feb;19(1):33-9
pubmed: 8197891
Br J Addict. 1988 Apr;83(4):393-402
pubmed: 3395719
Neuroimage. 2007 Feb 1;34(3):879-87
pubmed: 17127079
Alcohol Clin Exp Res. 2020 Jan;44(1):178-187
pubmed: 31912524
Magn Reson Med. 2003 Sep;50(3):599-607
pubmed: 12939768
Brain Imaging Behav. 2020 Oct;14(5):1731-1746
pubmed: 31073695
Neuropsychologia. 1971 Mar;9(1):97-113
pubmed: 5146491
Alcohol. 2010 May;44(3):201-10
pubmed: 20682188
Alcohol. 2008 Jun;42(4):269-75
pubmed: 18539247
Radiology. 2005 Mar;234(3):909-16
pubmed: 15734942
Brain. 1990 Feb;113 ( Pt 1):27-47
pubmed: 2302536
Addiction. 1993 Jun;88(6):791-804
pubmed: 8329970
Lancet Psychiatry. 2014 Aug;1(3):202-12
pubmed: 26360732
Neuropsychol Rev. 2007 Sep;17(3):239-57
pubmed: 17874302
Alcohol Clin Exp Res. 2020 May;44(5):1099-1111
pubmed: 32339317
Cereb Cortex. 2013 Mar;23(3):739-49
pubmed: 22437053
Neuroimage. 2002 Mar;15(3):708-18
pubmed: 11848714
Alcohol Clin Exp Res. 2002 Apr;26(4):558-64
pubmed: 11981133
Alcohol Clin Exp Res. 2019 Jun;43(6):1170-1179
pubmed: 30977902
Alcohol Clin Exp Res. 2018 May;42(5):889-896
pubmed: 29543332
Psychiatry Res Neuroimaging. 2019 Feb 28;284:21-28
pubmed: 30640144
Alcohol Clin Exp Res. 2019 May;43(5):812-821
pubmed: 30924954
Alcohol Clin Exp Res. 2011 Jun;35(6):1187-200
pubmed: 21410483
Alcohol Clin Exp Res. 2009 Apr;33(4):740-50
pubmed: 19170662
Magn Reson Med. 2015 Jan;73(1):102-16
pubmed: 24715426
J Psychiatr Res. 2021 Apr;136:140-148
pubmed: 33592385
J Magn Reson Imaging. 2014 Apr;39(4):931-9
pubmed: 24038544
Cortex. 2019 Jun;115:27-42
pubmed: 30738999
Nat Neurosci. 2008 Apr;11(4):389-97
pubmed: 18368045
Brain Struct Funct. 2010 Jun;214(5-6):655-67
pubmed: 20512370
Front Hum Neurosci. 2016 Mar 31;10:142
pubmed: 27064561
Neuroimage. 2014 Oct 1;99:180-90
pubmed: 24862074
Neuroimage. 2002 Mar;15(3):488-500
pubmed: 11848692
Biol Psychiatry. 2013 Oct 1;74(7):547-55
pubmed: 23587427
J Stud Alcohol. 1994 Mar;55(2):149-58
pubmed: 8189735
Nat Rev Neurosci. 2002 Aug;3(8):655-66
pubmed: 12154366
Sci Rep. 2018 Sep 27;8(1):14481
pubmed: 30262893
Magn Reson Med. 2007 Nov;58(5):1020-7
pubmed: 17969096