Ischemic heart disease: Cellular and molecular immune contributions of the pericardium.
Immune Cells
Inflammation
Ischemic Heart Disease
Pericardium
Journal
The international journal of biochemistry & cell biology
ISSN: 1878-5875
Titre abrégé: Int J Biochem Cell Biol
Pays: Netherlands
ID NLM: 9508482
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
30
06
2021
revised:
30
08
2021
accepted:
07
09
2021
pubmed:
21
9
2021
medline:
17
12
2021
entrez:
20
9
2021
Statut:
ppublish
Résumé
Ischemic heart disease promotes complex inflammatory and remodeling pathways which contribute to the development of chronic heart failure. Although blood-derived and local cardiac mediators have traditionally been linked with these processes, the pericardial space has more recently been noted as alternative contributor to the injury response in the heart. The pericardial space contains fluid rich in physiologically active mediators, and immunologically active adipose tissue, which are altered during myocardial infarction. Key immune cells in the pericardial fluid and adipose tissue have been identified which act as mediators for cell recruitment and function after myocardial infarction have been identified in experimental models. Here, we provide an overview of the current understanding of the inflammatory mechanisms of the pericardial space and their role in post-myocardial infarction remodeling and the potential for the use of the pericardial space as a delivery vehicle for treatments to modulate heart healing.
Identifiants
pubmed: 34543760
pii: S1357-2725(21)00157-6
doi: 10.1016/j.biocel.2021.106076
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106076Subventions
Organisme : CIHR
Pays : Canada
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.