Extracellular matrix protein N-glycosylation mediates immune self-tolerance in

Animals Drosophila Proteins / genetics Drosophila melanogaster / growth & development Extracellular Matrix Proteins / genetics Glycosylation Hemocytes Immune Tolerance / immunology Janus Kinases / genetics Mutation Self Tolerance
autoimmunity innate immunity protein N-glycosylation self-recognition self-tolerance

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
28 09 2021
Historique:
accepted: 26 07 2021
entrez: 21 9 2021
pubmed: 22 9 2021
medline: 8 10 2021
Statut: ppublish

Résumé

In order to respond to infection, hosts must distinguish pathogens from their own tissues. This allows for the precise targeting of immune responses against pathogens and also ensures self-tolerance, the ability of the host to protect self tissues from immune damage. One way to maintain self-tolerance is to evolve a self signal and suppress any immune response directed at tissues that carry this signal. Here, we characterize the

Identifiants

DOI: 10.1073/pnas.2017460118 PMID: 34544850 PMC: PMC8488588
pubmed: 34544850
pii: 2017460118
doi: 10.1073/pnas.2017460118
pmc: PMC8488588
pii:
doi:

Substances chimiques

Drosophila Proteins 0
Extracellular Matrix Proteins 0
Janus Kinases EC 2.7.10.2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAMS NIH HHS
ID : R15 AR070505
Pays : United States
Organisme : NIH HHS
ID : P40 OD018537
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM133760
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI081879
Pays : United States
Organisme : NIA NIH HHS
ID : R15 AG074113
Pays : United States

Informations de copyright

Copyright © 2021 the Author(s). Published by PNAS.

Déclaration de conflit d'intérêts

The authors declare no competing interest.

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Auteurs

Nathan T Mortimer (NT)

School of Biological Sciences, Illinois State University, Normal, IL 61790; ntmorti@ilstu.edu.
ORCID: 0000-0003-3787-9445

Mary L Fischer (ML)

School of Biological Sciences, Illinois State University, Normal, IL 61790.

Ashley L Waring (AL)

School of Biological Sciences, Illinois State University, Normal, IL 61790.

Pooja Kr (P)

School of Biological Sciences, Illinois State University, Normal, IL 61790.

Balint Z Kacsoh (BZ)

Epigenetics Institute, Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104.
ORCID: 0000-0001-9171-0611

Susanna E Brantley (SE)

Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305.
ORCID: 0000-0002-2420-1275

Erin S Keebaugh (ES)

Department of Biology, Emory University, Atlanta, GA 30322.

Joshua Hill (J)

School of Biological Sciences, Illinois State University, Normal, IL 61790.
ORCID: 0000-0001-8383-3830

Chris Lark (C)

School of Biological Sciences, Illinois State University, Normal, IL 61790.

Julia Martin (J)

School of Biological Sciences, Illinois State University, Normal, IL 61790.

Pravleen Bains (P)

School of Biological Sciences, Illinois State University, Normal, IL 61790.

Jonathan Lee (J)

School of Biological Sciences, Illinois State University, Normal, IL 61790.

Alysia D Vrailas-Mortimer (AD)

School of Biological Sciences, Illinois State University, Normal, IL 61790.
ORCID: 0000-0001-5927-096X

Todd A Schlenke (TA)

Department of Entomology, University of Arizona, Tucson, AZ 85719.
ORCID: 0000-0003-3091-3057

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Extracellular matrix protein N-glycosylation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'arthropode › Protéines d'insecte › Protéines de Drosophila › Extracellular matrix protein N-glycosylation...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Drosophila melanogaster › Extracellular matrix protein N-glycosylation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Extracellular matrix protein N-glycosylation...
questionsmedicales.fr › Métabolisme › Métabolisme glucidique › Glycosylation › Extracellular matrix protein N-glycosylation...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Sang › Cellules sanguines › Hémocytes › Extracellular matrix protein N-glycosylation...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunomodulation › Tolérance immunitaire › Extracellular matrix protein N-glycosylation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-tyrosine kinases › Janus kinases › Extracellular matrix protein N-glycosylation...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Extracellular matrix protein N-glycosylation...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunomodulation › Tolérance immunitaire › Autotolérance › Extracellular matrix protein N-glycosylation...