Functional roles of polyamines and their metabolite acrolein in eukaryotic cells.
Acrolein
/ metabolism
Animals
Atherosclerosis
Brain Infarction
/ metabolism
C-Reactive Protein
/ analysis
Dementia
/ metabolism
Eukaryotic Cells
/ metabolism
Humans
Interleukin-6
/ blood
Peptide Initiation Factors
/ physiology
Polyamines
/ chemistry
Protein Biosynthesis
/ physiology
Proteins
/ chemistry
RNA-Binding Proteins
/ physiology
Sjogren's Syndrome
/ metabolism
Eukaryotic Translation Initiation Factor 5A
Acrolein
Brain infarction
Dementia
PC-Acro
Polyamines
Protein synthesis
RNA
Reactive oxygen species
Spermidine
Spermine
Journal
Amino acids
ISSN: 1438-2199
Titre abrégé: Amino Acids
Pays: Austria
ID NLM: 9200312
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
26
06
2021
accepted:
24
08
2021
pubmed:
22
9
2021
medline:
5
2
2022
entrez:
21
9
2021
Statut:
ppublish
Résumé
Among low molecular weight substances, polyamines (spermidine, spermine and their precursor putrescine) are present in eukaryotic cells at the mM level together with ATP and glutathione. It is expected therefore that polyamines play important roles in cell proliferation and viability. Polyamines mainly exist as a polyamine-RNA complex and regulate protein synthesis. It was found that polyamines enhance translation from inefficient mRNAs. The detailed mechanisms of polyamine stimulation of specific kinds of protein syntheses and the physiological functions of these proteins are described in this review. Spermine is metabolized into acrolein (CH
Identifiants
pubmed: 34546444
doi: 10.1007/s00726-021-03073-w
pii: 10.1007/s00726-021-03073-w
doi:
Substances chimiques
IL6 protein, human
0
Interleukin-6
0
Peptide Initiation Factors
0
Polyamines
0
Proteins
0
RNA-Binding Proteins
0
Acrolein
7864XYD3JJ
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1473-1492Subventions
Organisme : kakenhi
ID : 21K06714
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.
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