Treatment and Prophylaxis of Post-pericardiotomy Syndrome in Cardiac Surgery Patients: a Systematic Review.


Journal

Cardiovascular drugs and therapy
ISSN: 1573-7241
Titre abrégé: Cardiovasc Drugs Ther
Pays: United States
ID NLM: 8712220

Informations de publication

Date de publication:
08 2023
Historique:
accepted: 06 09 2021
medline: 3 8 2023
pubmed: 22 9 2021
entrez: 21 9 2021
Statut: ppublish

Résumé

Post-pericardiotomy syndrome (PPS) is a common complication of cardiac surgery. This systematic review aimed to investigate the efficacy of colchicine, indomethacin, and dexamethasone in the treatment and prophylaxis of PPS. Literature research was carried out using PubMed. Studies investigating ≥ 10 patients with clinically PPS treated with colchicine, dexamethasone, and indomethacin and compared with placebo were included. Animal or in vitro experiments, studies on < 10 patients, case reports, congress reports, and review articles were excluded. Cochrane risk-of-bias tool for randomized trials (RoB2) was used for the quality assessment of studies. Seven studies were included. Among studies with postoperative colchicine treatment, two of them demonstrated a significant reduction of PPS. In the single pre-surgery colchicine administration study, a decrease of PPS cases was registered. Indomethacin pre-surgery administration was linked to a reduction of PPS. No significant result emerged with preoperative dexamethasone intake. Better outcomes have been registered when colchicine and indomethacin were administered as primary prophylactic agents in preventing PPS and PE. Further RCT studies are needed to confirm these results.

Identifiants

pubmed: 34546452
doi: 10.1007/s10557-021-07261-4
pii: 10.1007/s10557-021-07261-4
pmc: PMC10397136
doi:

Substances chimiques

Colchicine SML2Y3J35T
Indomethacin XXE1CET956
Dexamethasone 7S5I7G3JQL

Types de publication

Systematic Review Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

771-779

Informations de copyright

© 2021. The Author(s).

Références

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Auteurs

Omar Giacinto (O)

Department of Cardiovascular Surgery, University Campus Bio-Medico, Rome, Italy.

Alessandro Minati (A)

Department of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.

Mario Lusini (M)

Department of Cardiovascular Surgery, University Campus Bio-Medico, Rome, Italy.

Francesco Cardetta (F)

Department of Cardiovascular Surgery, University Campus Bio-Medico, Rome, Italy.

Sara Saltarocchi (S)

Department of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy. sara.saltarocchi@uniroma1.it.

Mizar D'Abramo (M)

Department of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.

Fabio Miraldi (F)

Department of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.

Massimo Chello (M)

Department of Cardiovascular Surgery, University Campus Bio-Medico, Rome, Italy.

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