Early oseltamivir reduces risk for influenza-associated aspergillosis in a double-hit murine model.
Animals
Aspergillosis
/ drug therapy
Aspergillus
Aspergillus fumigatus
Coinfection
/ drug therapy
Disease Models, Animal
Humans
Influenza, Human
/ complications
Invasive Pulmonary Aspergillosis
/ drug therapy
Mice
Oseltamivir
/ pharmacology
Pulmonary Aspergillosis
/ drug therapy
X-Ray Microtomography
Aspergillus fumigatus
Influenza
influenza-associated pulmonary aspergillosis
multimodal preclinical imaging-supported mouse model
oseltamivir
Journal
Virulence
ISSN: 2150-5608
Titre abrégé: Virulence
Pays: United States
ID NLM: 101531386
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
entrez:
21
9
2021
pubmed:
22
9
2021
medline:
16
4
2022
Statut:
ppublish
Résumé
Invasive pulmonary aspergillosis (IPA) is a life-threatening fungal infection occurring mainly in immunocompromised patients. We recently identified IPA as an emerging co-infection with high mortality in critically ill, but otherwise immunocompetent influenza patients. The neuraminidase inhibitor oseltamivir is the current standard-of-care treatment in hospitalized influenza patients; however, its efficacy in influenza-associated pulmonary aspergillosis (IAPA) is not known. Therefore, we have established an imaging-supported double-hit mouse model to investigate the therapeutic effect of oseltamivir on the development of IAPA. Immunocompetent mice received intranasal instillation influenza A or PBS followed by orotracheal inoculation with
Identifiants
pubmed: 34546839
doi: 10.1080/21505594.2021.1974327
pmc: PMC8923074
doi:
Substances chimiques
Oseltamivir
20O93L6F9H
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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