Usefulness of Xpert® Carba-R on enrichment broth for the early detection of carbapenemase-producing Enterobacterales.

Bacterial Proteins / genetics Bacteriological Techniques Enterobacteriaceae Infections / diagnosis Humans Molecular Diagnostic Techniques Sensitivity and Specificity beta-Lactamases / genetics
CPE Rectal swabs Screening

Journal

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
ISSN: 1878-3511
Titre abrégé: Int J Infect Dis
Pays: Canada
ID NLM: 9610933

Informations de publication

Date de publication:
Nov 2021
Historique:
received: 28 06 2021
revised: 10 09 2021
accepted: 15 09 2021
pubmed: 22 9 2021
medline: 15 12 2021
entrez: 21 9 2021
Statut: ppublish

Résumé

Early detection of patients colonized with carbapenemase-producing Enterobacterales is crucial to limit their spread. Molecular biology tests are rapid but might miss low-level carriage. Culture-based methods using enrichment are cheap and detect low-level carriage but cause delay. Two clinical cases are reported, which demonstrated that molecular biology (Xpert® Carb-R) on enriched broth cumulates advantages of both strategies. In both cases, this strategy enabled early detection of patients colonized at low-level with carbapenemase-producing Enterobacterales because it saved 24 hours in detection time.

Identifiants

DOI: 10.1016/j.ijid.2021.09.031 PMID: 34547497
pubmed: 34547497
pii: S1201-9712(21)00740-2
doi: 10.1016/j.ijid.2021.09.031
pii:
doi:

Substances chimiques

Bacterial Proteins 0
beta-Lactamases EC 3.5.2.6
carbapenemase EC 3.5.2.6

Types de publication

Case Reports

Langues

eng

Sous-ensembles de citation

IM

Pagination

183-185

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Auteurs

Delphine Girlich (D)

UMR-S 1184, Paris-Saclay University, Le Kremlin-Bicêtre, France.

Souad Ouzani (S)

Bacteriology-Hygiene unit, Assistance Publique - Hôpitaux de Paris, Bicêtre Hospital, Le Kremlin-Bicêtre, France.

Isabelle Langlois (I)

Bacteriology-Hygiene unit, Assistance Publique - Hôpitaux de Paris, Bicêtre Hospital, Le Kremlin-Bicêtre, France.

Nicolas Fortineau (N)

UMR-S 1184, Paris-Saclay University, Le Kremlin-Bicêtre, France; Bacteriology-Hygiene unit, Assistance Publique - Hôpitaux de Paris, Bicêtre Hospital, Le Kremlin-Bicêtre, France.

Thierry Naas (T)

UMR-S 1184, Paris-Saclay University, Le Kremlin-Bicêtre, France; Bacteriology-Hygiene unit, Assistance Publique - Hôpitaux de Paris, Bicêtre Hospital, Le Kremlin-Bicêtre, France; Associated French National Reference Center for Antibiotic Resistance: Carbapenemase-producing Enterobacteriaceae, Le Kremlin-Bicêtre, France.

Laurent Dortet (L)

UMR-S 1184, Paris-Saclay University, Le Kremlin-Bicêtre, France; Bacteriology-Hygiene unit, Assistance Publique - Hôpitaux de Paris, Bicêtre Hospital, Le Kremlin-Bicêtre, France; Associated French National Reference Center for Antibiotic Resistance: Carbapenemase-producing Enterobacteriaceae, Le Kremlin-Bicêtre, France. Electronic address: laurent.dortet@aphp.fr.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Usefulness of Xpert® Carba-R on enrichment...
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Techniques microbiologiques › Techniques bactériologiques › Usefulness of Xpert® Carba-R on enrichment...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Enterobacteriaceae › Usefulness of Xpert® Carba-R on enrichment...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Usefulness of Xpert® Carba-R on enrichment...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Techniques de diagnostic moléculaire › Usefulness of Xpert® Carba-R on enrichment...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Sensibilité et spécificité › Usefulness of Xpert® Carba-R on enrichment...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › bêta-Lactamases › Usefulness of Xpert® Carba-R on enrichment...