A BRCA1 Coiled-Coil Domain Variant Disrupting PALB2 Interaction Promotes the Development of Mammary Tumors and Confers a Targetable Defect in Homologous Recombination Repair.

Animals Apoptosis BRCA1 Protein / physiology BRCA2 Protein / physiology Cell Proliferation Fanconi Anemia Complementation Group N Protein / physiology Female Gene Expression Regulation, Neoplastic Homologous Recombination Mammary Neoplasms, Animal / genetics Mice Mice, Knockout Recombinational DNA Repair Tumor Cells, Cultured Tumor Suppressor Protein p53 / physiology

Journal

Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R

Informations de publication

Date de publication:
15 12 2021
Historique:
received: 05 05 2021
revised: 21 08 2021
accepted: 20 09 2021
pubmed: 23 9 2021
medline: 7 1 2022
entrez: 22 9 2021
Statut: ppublish

Résumé

The

Identifiants

DOI: 10.1158/0008-5472.CAN-21-1415 PMID: 34548335 PMC: PMC7612117
pubmed: 34548335
pii: 0008-5472.CAN-21-1415
doi: 10.1158/0008-5472.CAN-21-1415
pmc: PMC7612117
mid: EMS135513
doi:

Substances chimiques

BRCA1 Protein 0
BRCA2 Protein 0
BRCA2 protein, mouse 0
Brca1 protein, mouse 0
Fanconi Anemia Complementation Group N Protein 0
Palb2 protein, mouse 0
Trp53 protein, mouse 0
Tumor Suppressor Protein p53 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6171-6182

Subventions

Organisme : NCI NIH HHS
ID : R01 CA138804
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA262227
Pays : United States
Organisme : ZonMw
ID : ZONMW_91814643
Pays : Netherlands

Commentaires et corrections

Type : CommentIn

Informations de copyright

©2021 American Association for Cancer Research.

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Auteurs

Emilia M Pulver (EM)

Oncode Institute and Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
ORCID: 0000-0001-5748-1835

Chirantani Mukherjee (C)

Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.
ORCID: 0000-0002-7738-5135

Gerarda van de Kamp (G)

Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.

Stefan J Roobol (SJ)

Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.
Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
ORCID: 0000-0002-3051-4753

Magdalena B Rother (MB)

Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.

Hanneke van der Gulden (H)

Oncode Institute and Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

Roebi de Bruijn (R)

Oncode Institute and Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Oncode Institute and Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

Maria Valeria Lattanzio (MV)

Oncode Institute and Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

Eline van der Burg (E)

Oncode Institute and Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

Anne Paulien Drenth (AP)

Oncode Institute and Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

Nicole S Verkaik (NS)

Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.

Kerstin Hahn (K)

Oncode Institute and Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

Sjoerd Klarenbeek (S)

Experimental Animal Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
ORCID: 0000-0002-1891-1940

Renske de Korte-Grimmerink (R)

Preclinical Intervention Unit, Mouse Clinic for Cancer and Aging (MCCA), The Netherlands Cancer Institute, Amsterdam, the Netherlands.

Marieke van de Ven (M)

Preclinical Intervention Unit, Mouse Clinic for Cancer and Aging (MCCA), The Netherlands Cancer Institute, Amsterdam, the Netherlands.
ORCID: 0000-0001-6779-9353

Colin E J Pritchard (CEJ)

Transgenic Core Facility, Mouse Clinic for Cancer and Aging (MCCA), The Netherlands Cancer Institute, Amsterdam, the Netherlands.
ORCID: 0000-0001-7848-9377

Ivo J Huijbers (IJ)

Transgenic Core Facility, Mouse Clinic for Cancer and Aging (MCCA), The Netherlands Cancer Institute, Amsterdam, the Netherlands.

Bing Xia (B)

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey.

Dik C van Gent (DC)

Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.
ORCID: 0000-0003-1473-8148

Jeroen Essers (J)

Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.
Department of Radiation Oncology, Department of Vascular Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands.

Haico van Attikum (H)

Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
ORCID: 0000-0001-8590-0240

Arnab Ray Chaudhuri (A)

Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.

Peter Bouwman (P)

Oncode Institute and Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands. j.jonkers@nki.nl r.j.p.bouwman@lacdr.leidenuniv.nl.
ORCID: 0000-0002-9252-5896

Jos Jonkers (J)

Oncode Institute and Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands. j.jonkers@nki.nl r.j.p.bouwman@lacdr.leidenuniv.nl.
ORCID: 0000-0002-9264-9792

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A BRCA1 Coiled-Coil Domain Variant Disrupting...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › A BRCA1 Coiled-Coil Domain Variant Disrupting...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéine BRCA1 › A BRCA1 Coiled-Coil Domain Variant Disrupting...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéine BRCA2 › A BRCA1 Coiled-Coil Domain Variant Disrupting...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › A BRCA1 Coiled-Coil Domain Variant Disrupting...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéine du groupe de complémentation N de l'anémie de Fanconi › A BRCA1 Coiled-Coil Domain Variant Disrupting...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › A BRCA1 Coiled-Coil Domain Variant Disrupting...
questionsmedicales.fr › Phénomènes génétiques › Recombinaison génétique › Recombinaison homologue › A BRCA1 Coiled-Coil Domain Variant Disrupting...
questionsmedicales.fr › Maladies de l'animal › Tumeurs mammaires de l'animal › A BRCA1 Coiled-Coil Domain Variant Disrupting...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A BRCA1 Coiled-Coil Domain Variant Disrupting...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › A BRCA1 Coiled-Coil Domain Variant Disrupting...
questionsmedicales.fr › Phénomènes génétiques › Recombinaison génétique › Recombinaison homologue › Réparation de l'ADN par recombinaison › A BRCA1 Coiled-Coil Domain Variant Disrupting...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › A BRCA1 Coiled-Coil Domain Variant Disrupting...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Protéine p53 suppresseur de tumeur › A BRCA1 Coiled-Coil Domain Variant Disrupting...