The human liver microenvironment shapes the homing and function of CD4

CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Cytokines / immunology Humans Immunologic Memory Liver / immunology Monitoring, Immunologic
T lymphocytes cellular immunity hepatitis B immunology liver immunology

Journal

Gut
ISSN: 1468-3288
Titre abrégé: Gut
Pays: England
ID NLM: 2985108R

Informations de publication

Date de publication:
07 2022
Historique:
received: 09 12 2020
accepted: 19 08 2021
pubmed: 23 9 2021
medline: 10 6 2022
entrez: 22 9 2021
Statut: ppublish

Résumé

Tissue-resident memory T cells (T We used multiparametric flow cytometry, histological assessment and novel human tissue coculture systems to interrogate the ex vivo phenotype, function and generation of the intrahepatic CD4 Hepatic CD4 High and intermediate CD69 expressions mark human hepatic CD4

Identifiants

DOI: 10.1136/gutjnl-2020-323771 PMID: 34548339 PMC: PMC9185819
pubmed: 34548339
pii: gutjnl-2020-323771
doi: 10.1136/gutjnl-2020-323771
pmc: PMC9185819
doi:

Substances chimiques

Cytokines 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1399-1411

Subventions

Organisme : MRF
ID : MRF_MRF-044-0004-F-GILL-C0823
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : MRF
ID : MRF_MRF-044-0005-F-TRIV-C0824
Pays : United Kingdom
Organisme : Department of Health
ID : PB-PG-0614-34087
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 107389/Z/15/Z
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 26813
Pays : United Kingdom
Organisme : MRF
ID : MRF_MRF-169-0001-F-STAM-C0826
Pays : United Kingdom

Informations de copyright

© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: BW collaborated with and received funding from Bioniz. LJP sat on advisory boards/provided consultancy for Gilead Sciences and SQZ Biotech. KA was funded by a studentship with Dr Falk. MKM received research funding from Gilead Sciences, Hoffmann La Roche and Immunocore. MKM sat on advisory boards/provided consultancy for Gilead, Hoffmann La Roche, Immunocore, VIR, Galapagos NV, GSK, Abbvie and Freeline. ZS collaborated with Bioniz and AstraZeneca and consulted for Boehringer Ingelheim. All other authors declare no conflict of interest.

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Auteurs

Benjamin G Wiggins (BG)

Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Institute of Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK.
Centre for Liver and Gastrointestinal Research, University of Birmingham, Birmingham, UK.
ORCID: 0000-0001-5215-2004

Laura J Pallett (LJ)

Institute of Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK.
ORCID: 0000-0002-4161-9462

Xiaoyan Li (X)

Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Department of Infectious Diseases and Guangdong Provincial Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Scott P Davies (SP)

Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Centre for Liver and Gastrointestinal Research, University of Birmingham, Birmingham, UK.

Oliver E Amin (OE)

Institute of Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK.

Upkar S Gill (US)

Immunobiology, Blizard Institute, London, UK.

Stephanie Kucykowicz (S)

Institute of Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK.

Arzoo M Patel (AM)

Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Centre for Liver and Gastrointestinal Research, University of Birmingham, Birmingham, UK.

Konstantinos Aliazis (K)

Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Centre for Liver and Gastrointestinal Research, University of Birmingham, Birmingham, UK.

Yuxin S Liu (YS)

Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Centre for Liver and Gastrointestinal Research, University of Birmingham, Birmingham, UK.

Gary M Reynolds (GM)

Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Centre for Liver and Gastrointestinal Research, University of Birmingham, Birmingham, UK.

Brian R Davidson (BR)

Surgery, Royal Free Campus, UCL Medical School, London, UK.

Amir Gander (A)

Tissue Access for Patient Benefit, University College London, London, UK.

Tu Vinh Luong (TV)

Department of Cellular Pathology, Royal Free Hospital, London, UK.

Gideon M Hirschfield (GM)

Centre for Liver and Gastrointestinal Research, University of Birmingham, Birmingham, UK.
Centre for Liver Research, National Institute for Health Research Biomedical Research Unit, University of Birmingham, Birmingham, UK.

Patrick T F Kennedy (PTF)

Immunobiology, Blizard Institute, London, UK.
ORCID: 0000-0001-9201-0094

Yuehua Huang (Y)

Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Guangdong Provincial Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

Mala K Maini (MK)

Division of Infection and Immunity, Rayne Institute, University College London, London, UK z.stamataki@bham.ac.uk m.maini@ucl.ac.uk.

Zania Stamataki (Z)

Centre for Liver and Gastrointestinal Research, University of Birmingham, Birmingham, UK z.stamataki@bham.ac.uk m.maini@ucl.ac.uk.
ORCID: 0000-0003-3823-4497

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Classifications MeSH

questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › The human liver microenvironment shapes the...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › The human liver microenvironment shapes the...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › The human liver microenvironment shapes the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The human liver microenvironment shapes the...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Mémoire immunologique › The human liver microenvironment shapes the...
questionsmedicales.fr › Système digestif › Foie › The human liver microenvironment shapes the...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Tests immunologiques › Monitorage immunologique › The human liver microenvironment shapes the...