Cyp2c44 epoxygenase-derived epoxyeicosatrienoic acids in vascular smooth muscle cells elicit vasoconstriction of the murine ophthalmic artery.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 09 2021
21 09 2021
Historique:
received:
11
06
2021
accepted:
02
09
2021
entrez:
22
9
2021
pubmed:
23
9
2021
medline:
31
12
2021
Statut:
epublish
Résumé
Cytochrome P450 (CYP) signalling pathway has been shown to play a vital role in the vasoreactivity of wild type mouse ophthalmic artery. In this study, we determined the expression, vascular responses and potential mechanisms of the CYP-derived arachidonic acid metabolites. The expression of murine CYP (Cyp2c44) and soluble epoxide hydrolase (sEH) in the wild type ophthalmic artery was determined with immunofluorescence, which showed predominant expression of Cyp2c44 in the vascular smooth muscle cells (VSMC), while sEH was found mainly in the endothelium of the wild type ophthalmic artery. Artery of Cyp2c44
Identifiants
pubmed: 34548575
doi: 10.1038/s41598-021-98236-w
pii: 10.1038/s41598-021-98236-w
pmc: PMC8455677
doi:
Substances chimiques
Fatty Acids, Monounsaturated
0
Cyp2c23 protein, mouse
EC 1.14.14.1
Cytochrome P450 Family 2
EC 1.14.14.1
Epoxide Hydrolases
EC 3.3.2.-
Ephx2 protein, mouse
EC 3.3.2.10
eicosenoic acid
UDX6WPL94T
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18764Informations de copyright
© 2021. The Author(s).
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