Cyp2c44 epoxygenase-derived epoxyeicosatrienoic acids in vascular smooth muscle cells elicit vasoconstriction of the murine ophthalmic artery.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
21 09 2021
Historique:
received: 11 06 2021
accepted: 02 09 2021
entrez: 22 9 2021
pubmed: 23 9 2021
medline: 31 12 2021
Statut: epublish

Résumé

Cytochrome P450 (CYP) signalling pathway has been shown to play a vital role in the vasoreactivity of wild type mouse ophthalmic artery. In this study, we determined the expression, vascular responses and potential mechanisms of the CYP-derived arachidonic acid metabolites. The expression of murine CYP (Cyp2c44) and soluble epoxide hydrolase (sEH) in the wild type ophthalmic artery was determined with immunofluorescence, which showed predominant expression of Cyp2c44 in the vascular smooth muscle cells (VSMC), while sEH was found mainly in the endothelium of the wild type ophthalmic artery. Artery of Cyp2c44

Identifiants

pubmed: 34548575
doi: 10.1038/s41598-021-98236-w
pii: 10.1038/s41598-021-98236-w
pmc: PMC8455677
doi:

Substances chimiques

Fatty Acids, Monounsaturated 0
Cyp2c23 protein, mouse EC 1.14.14.1
Cytochrome P450 Family 2 EC 1.14.14.1
Epoxide Hydrolases EC 3.3.2.-
Ephx2 protein, mouse EC 3.3.2.10
eicosenoic acid UDX6WPL94T

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

18764

Informations de copyright

© 2021. The Author(s).

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Auteurs

Jiong Hu (J)

Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt, Germany.
German Centre of Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany.

Marco Sisignano (M)

Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, University Hospital, Goethe-University, Frankfurt, Germany.
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt, Germany.

Roman Brecht (R)

Department of Ophthalmology, University Medical Centre of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.

Natarajan Perumal (N)

Department of Ophthalmology, University Medical Centre of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.

Carlo Angioni (C)

Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, University Hospital, Goethe-University, Frankfurt, Germany.

Iris-Sofia Bibli (IS)

Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt, Germany.
German Centre of Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany.

Beate Fisslthaler (B)

Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt, Germany.
German Centre of Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany.

Hartmut Kleinert (H)

Department of Pharmacology, University Medical Centre of the Johannes Gutenberg University Mainz, Mainz, Germany.

Norbert Pfeiffer (N)

Department of Ophthalmology, University Medical Centre of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.

Ingrid Fleming (I)

Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt, Germany.
German Centre of Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt, Germany.

Caroline Manicam (C)

Department of Ophthalmology, University Medical Centre of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany. caroline.manicam@unimedizin-mainz.de.

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