Novel Immunological and Therapeutic Insights in Guillain-Barré Syndrome and CIDP.
Chronic inflammatory demyelinating polyradiculoneuropathy
Guillain-Barré syndrome
Immunomodulatory treatments
Inflammatory neuropathies
Journal
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
ISSN: 1878-7479
Titre abrégé: Neurotherapeutics
Pays: United States
ID NLM: 101290381
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
accepted:
02
09
2021
pubmed:
23
9
2021
medline:
31
3
2022
entrez:
22
9
2021
Statut:
ppublish
Résumé
Inflammatory neuropathies are a heterogeneous group of rare diseases of the peripheral nervous system that include acute and chronic diseases, such as Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). The etiology and pathophysiological mechanisms of inflammatory neuropathies are only partly known, but are considered autoimmune disorders in which an aberrant immune response, including cellular and humoral components, is directed towards components of the peripheral nerve causing demyelination and axonal damage. Therapy of these disorders includes broad-spectrum immunomodulatory and immunosuppressive treatments, such as intravenous immunoglobulin, corticosteroids, or plasma exchange. However, a significant proportion of patients do not respond to any of these therapies, and treatment selection is not optimized according to disease pathophysiology. Therefore, research on disease pathophysiology aiming to reveal clinically and functionally relevant disease mechanisms and the development of new treatment approaches are needed to optimize disease outcomes in CIDP and GBS. This topical review describes immunological progress that may help guide therapeutic strategies in the future in these two disorders.
Identifiants
pubmed: 34549385
doi: 10.1007/s13311-021-01117-3
pii: 10.1007/s13311-021-01117-3
pmc: PMC8455117
doi:
Substances chimiques
Immunoglobulins, Intravenous
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2222-2235Informations de copyright
© 2021. The American Society for Experimental NeuroTherapeutics, Inc.
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