Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study.
Journal
Acta cirurgica brasileira
ISSN: 1678-2674
Titre abrégé: Acta Cir Bras
Pays: Brazil
ID NLM: 9103983
Informations de publication
Date de publication:
2021
2021
Historique:
received:
09
04
2021
accepted:
08
07
2021
entrez:
22
9
2021
pubmed:
23
9
2021
medline:
25
9
2021
Statut:
epublish
Résumé
To investigate whether renal modifications occur following treatment with dutasteride or finasteride. Twenty-four male rats were divided into three groups: control (that received distilled water), dutasteride (0.5 mg/kg/day), and finasteride (5 mg/kg/day) groups. All administrations were given by gavage for 40 consecutive days. After inducing euthanasia, blood was collected for urea and creatinine analyses, and both the kidneys were collected for stereological analyses of kidney morphology. Serum urea and creatinine levels were increased in both the finasteride and the dutasteride groups compared with those in the control group. In addition, kidney weight, kidney volume, cortical volume, glomerular volumetric density, and mean glomerular volume were reduced in both treatment groups. Finally, the number of glomeruli per kidney was reduced by 26.8% in the finasteride group and by 51.6% in the dutasteride group compared with that in the control group. The 5-ARIs finasteride and dutasteride promoted morphological and functional damages in rat kidneys. In addition, rats in the dutasteride group showed more severe renal modifications than those in the finasteride group.
Identifiants
pubmed: 34550196
pii: S0102-86502021000700206
doi: 10.1590/ACB360703
pmc: PMC8448540
pii:
doi:
Substances chimiques
5-alpha Reductase Inhibitors
0
Finasteride
57GNO57U7G
Dutasteride
O0J6XJN02I
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e360703Références
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