Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
20
12
2020
revised:
26
07
2021
accepted:
17
09
2021
pubmed:
24
9
2021
medline:
15
3
2022
entrez:
23
9
2021
Statut:
ppublish
Résumé
The degree of metastatic disease varies widely among patients with cancer and affects clinical outcomes. However, the biological and functional differences that drive the extent of metastasis are poorly understood. We analyzed primary tumors and paired metastases using a multifluorescent lineage-labeled mouse model of pancreatic ductal adenocarcinoma (PDAC)-a tumor type in which most patients present with metastases. Genomic and transcriptomic analysis revealed an association between metastatic burden and gene amplification or transcriptional upregulation of
Identifiants
pubmed: 34551968
pii: 2159-8290.CD-20-1826
doi: 10.1158/2159-8290.CD-20-1826
pmc: PMC8831468
mid: NIHMS1744167
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
542-561Subventions
Organisme : NIDDK NIH HHS
ID : K08 DK109492
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : CIHR
ID : 388785
Pays : Canada
Organisme : NCI NIH HHS
ID : R01 CA229803
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA200561
Pays : United States
Organisme : NCI NIH HHS
ID : F31 CA236269
Pays : United States
Organisme : NCI NIH HHS
ID : F32 CA221094
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK050306
Pays : United States
Organisme : NCI NIH HHS
ID : K99 CA252153
Pays : United States
Informations de copyright
©2021 The Authors; Published by the American Association for Cancer Research.
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