Lipidomic Alterations and PPAR
Animals
Antioxidants
/ pharmacology
Apoptosis
Disease Models, Animal
Endometriosis
/ drug therapy
Endometrium
/ drug effects
Female
Gene Expression Profiling
Humans
Lipid Metabolism
/ drug effects
Lipidomics
PPAR alpha
/ genetics
Rats
Rats, Sprague-Dawley
Resveratrol
/ pharmacology
Stromal Cells
/ drug effects
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2021
2021
Historique:
received:
01
04
2021
revised:
15
08
2021
accepted:
17
08
2021
entrez:
23
9
2021
pubmed:
24
9
2021
medline:
16
2
2022
Statut:
epublish
Résumé
Endometriosis is an estrogen-dependent chronic inflammatory disease that affects approximately 10% of women of reproductive age and up to 50% of women with infertility. The heterogeneity of the disease makes accurate diagnosis and treatment a clinical challenge. In this study, we generated two models of endometriosis: the first in rats and the second using human ectopic endometrial stromal cells (HEcESCs) derived from the lesion tissues of endometriosis patients. We then applied resveratrol to assess its therapeutic potential. Resveratrol intervention had significant efficacy to attenuate lesion size and to rectify aberrant lipid profiles of model rats. Lipidomic analysis revealed significant lipidomic alterations, including notable increases of sphingolipids and decreases of both glycerolipids and most phospholipids. Upon resveratrol application, both proliferation capacity and invasiveness parameters decreased, and the early apoptosis proportion increased for HEcESCs. The activation of PPAR
Identifiants
pubmed: 34552688
doi: 10.1155/2021/9979953
pmc: PMC8452402
doi:
Substances chimiques
Antioxidants
0
PPAR alpha
0
Resveratrol
Q369O8926L
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
9979953Informations de copyright
Copyright © 2021 Zhengyun Chen et al.
Déclaration de conflit d'intérêts
The authors have declared that no conflict of interest exists.
Références
Biomed Pharmacother. 2017 Jul;91:220-228
pubmed: 28458160
Proc Natl Acad Sci U S A. 1983 May;80(9):2477-80
pubmed: 6573666
J Endocr Soc. 2017 Mar 15;1(4):359-369
pubmed: 29264492
Anal Chem. 2018 Jun 19;90(12):7608-7616
pubmed: 29807422
Sci Rep. 2017 May 31;7(1):2546
pubmed: 28566741
Biochimie. 2017 May;136:21-26
pubmed: 28013071
Front Physiol. 2018 Jan 23;9:14
pubmed: 29410629
Arteriosclerosis. 1984 Mar-Apr;4(2):154-64
pubmed: 6422917
J Clin Endocrinol Metab. 2015 Jul;100(7):E955-63
pubmed: 25996258
J Food Drug Anal. 2017 Jan;25(1):134-147
pubmed: 28911531
Cell Metab. 2013 Jun 4;17(6):1009-1020
pubmed: 23684622
Nat Rev Cardiol. 2019 Jul;16(7):389-406
pubmed: 30846875
J Transl Med. 2016 Jun 11;14(1):176
pubmed: 27286657
Hum Reprod Update. 2012 May-Jun;18(3):248-59
pubmed: 22371314
Fertil Steril. 2010 May 1;93(7):2433-6
pubmed: 19969295
Fertil Steril. 2009 Dec;92(6):2100-2
pubmed: 19580963
Hepatology. 2018 Feb;67(2):662-675
pubmed: 28960374
Cochrane Database Syst Rev. 2016 Apr 20;4:CD012165
pubmed: 27094925
Exp Biol Med (Maywood). 2009 Jan;234(1):28-34
pubmed: 18997104
J Minim Invasive Gynecol. 2018 Mar - Apr;25(3):426-433
pubmed: 28888701
Hum Reprod. 2013 Jan;28(1):178-88
pubmed: 23081870
Nature. 2015 Jun 25;522(7557):474-7
pubmed: 25970251
Phytother Res. 2019 Apr;33(4):1044-1054
pubmed: 30838714
Lancet. 2004 Nov 13-19;364(9447):1789-99
pubmed: 15541453
Minerva Ginecol. 2017 Oct;69(5):447-461
pubmed: 28271702
Mol Reprod Dev. 2019 Aug;86(8):1044-1052
pubmed: 31215101
Metabolism. 1997 Jul;46(7):735-9
pubmed: 9225824
Hum Reprod. 2012 Oct;27(10):2955-65
pubmed: 22859507
PLoS Genet. 2013;9(9):e1003801
pubmed: 24068966
Am J Reprod Immunol. 2016 Apr;75(4):486-92
pubmed: 26782781
J Biol Chem. 2000 Mar 17;275(11):8126-32
pubmed: 10713135
Reprod Sci. 2020 Oct;27(10):1943-1950
pubmed: 32542537
J Lipid Res. 2004 Nov;45(11):2025-37
pubmed: 15342691
Biotechnol Adv. 2018 Nov 1;36(6):1699-1708
pubmed: 29476886
Hum Reprod Update. 2021 Feb 19;27(2):367-392
pubmed: 33124671
J Headache Pain. 2019 Jan 31;20(1):11
pubmed: 30704400
Eur J Pharmacol. 2015 Feb 5;748:166-9
pubmed: 25218904
Hum Reprod. 2012 May;27(5):1292-9
pubmed: 22422778
J Nutr. 1994 May;124(5):615-20
pubmed: 8169652
Nutrition. 2019 Feb;58:7-10
pubmed: 30278430
EMBO Rep. 2004 Aug;5(8):777-82
pubmed: 15289826
Cell. 2015 Nov 5;163(4):960-74
pubmed: 26544941
Biol Reprod. 2011 Jan;84(1):106-12
pubmed: 20844278
Cell Metab. 2011 Nov 2;14(5):598-611
pubmed: 22055503
Fertil Steril. 2019 Feb;111(2):327-340
pubmed: 30527836
Biochem Pharmacol. 2013 May 1;85(9):1288-96
pubmed: 23422569
Cancer Res. 1996 Nov 1;56(21):4936-41
pubmed: 8895747
J Clin Immunol. 2005 Nov;25(6):582-91
pubmed: 16380821
Circulation. 2019 Jul 9;140(2):126-137
pubmed: 31116951