The role of IL-17 rs2275913, IL-17RC rs708567 and TGFB1 rs1800469 SNPs and IL-17A serum levels in patients with lupus nephritis.
Interleukin-17
Lupus nephritis
Receptors
Single nucleotide polymorphism
Systemic lupus erythematosus
Transforming growth factor beta1
Journal
Rheumatology international
ISSN: 1437-160X
Titre abrégé: Rheumatol Int
Pays: Germany
ID NLM: 8206885
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
18
06
2021
accepted:
13
09
2021
pubmed:
24
9
2021
medline:
21
1
2022
entrez:
23
9
2021
Statut:
ppublish
Résumé
Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease and polymorphisms in the cytokine genes and their receptors are thought to influence its development. The aim of this case-control study was to investigate the association of the IL-17A rs2275913, IL-17RC rs708567 and TGFB1 rs1800469 polymorphisms with SLE, its clinical manifestations and the polymorphisms influence on the IL-17A serum levels. Altogether 59 SLE patients with lupus nephritis and 95 healthy controls were genotyped by TaqMan assay. Serum levels were determined by Human IL-17A Platinum ELISA kit. From the studied polymorphisms, only TGFB1 T allele was found to be associated with SLE. Within the patient group, IL-17A GG genotype and TGFB1 -509T allele showed an association with the neurological disease and IL-17RC CC genotype appeared to be associated with lupus arthritis. The IL17A serum levels in the SLE and control groups (7.24 pg/ml and 5.76 pg/ml, respectively) did not show any statistical difference. A weak correlation between IL17A levels and SLEDAI-2K was observed. Our results indicate that IL-17A rs2275913, IL-17RCrs708567 and TGFB1 rs1800469 polymorphisms might play a role in the susceptibility and the clinical manifestations of SLE and IL-17A serum levels should be monitored in the course of the disease. The identification of subsets of SLE with an IL-17-driven disease could improve the therapeutic approach leading to more precise personalized treatment.
Identifiants
pubmed: 34554306
doi: 10.1007/s00296-021-04996-z
pii: 10.1007/s00296-021-04996-z
doi:
Substances chimiques
IL17A protein, human
0
Interleukin-17
0
Receptors, Interleukin-17
0
TGFB1 protein, human
0
Transforming Growth Factor beta1
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2205-2213Subventions
Organisme : Medical University-Sofia
ID : D-67/2016
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
de Morales J, Puig L, Dauden E et al (2020) Critical role of interleukin (IL)-17 in inflammatory and immune disorders: an updated review of the evidence focusing in controversies. Autoimm rev 19(1):102429. https://doi.org/10.1016/j.autrev.2019.102429
doi: 10.1016/j.autrev.2019.102429
Koga T, Ichinose K, Kawakami A, Tsokos GC (2019) The role of IL-17 in systemic lupus erythematosus and its potential as a therapeutictarget. Expert Rev Clin Immunol 15(6):629–637. https://doi.org/10.1080/1744666X.2019.1593141
doi: 10.1080/1744666X.2019.1593141
pubmed: 30874446
Hatton RD (2011) TGF-β in Th17 cell development: the truth is out there. Immunity 34(3):288–290. https://doi.org/10.1016/j.immuni.2011.03.009
doi: 10.1016/j.immuni.2011.03.009
pubmed: 21435582
pmcid: 3097895
Manolova I, Gerenova J, Ivanova M (2013) Serum levels of transforming growth factor-β1 (TGF-β1) in patients with systemic lupus erythematosus and Hashimoto’s thyroiditis. Eur Cytokine Netw 24(1):69–74. https://doi.org/10.1684/ecn.2013.0331
doi: 10.1684/ecn.2013.0331
pubmed: 23614931
Antiga E, Del Bianco E, Difonzo E, Fabbri P, Caproni M (2011) Serum levels of the regulatory cytokines transforming growth factor-β and interleukin-10 are reduced in patients with discoid lupus erythematosus. Lupus 20(6):556–560. https://doi.org/10.1177/0961203310392424
doi: 10.1177/0961203310392424
pubmed: 21372199
Peng Z, Zhan L, Chen S, Xu E (2011) Association of transforming growth factor-β1 gene C-509T and T869C polymorphisms with atherosclerotic cerebral infarction in the Chinese: a case-control study. Lipids Health Dis 10:100. https://doi.org/10.1186/1476-511X-10-100
doi: 10.1186/1476-511X-10-100
pubmed: 21679448
pmcid: 3129580
Grainger DJ, Heathcote K, Chiano M et al (1999) Genetic control of the circulating concentration of transforming growth factor type β1. Hum Mol Genet 8(1):93–97. https://doi.org/10.1093/hmg/8.1.93
doi: 10.1093/hmg/8.1.93
pubmed: 9887336
Crispin JC, Oukka M, Bayliss G et al (2008) Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys. J Immunol 181(12):8761–8766. https://doi.org/10.4049/jimmunol.181.12.8761
doi: 10.4049/jimmunol.181.12.8761
pubmed: 19050297
Yang J, Chu Y, Yang X et al (2009) Th17 and natural treg cell population dynamics in systemic lupus erythematosus. Arthritis Rheum 60(5):1472–1483. https://doi.org/10.1002/art.24499
doi: 10.1002/art.24499
pubmed: 19404966
Wong CK, Lit LCW, Tam LS et al (2008) Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity. Clin Immunol 127(3):385–393. https://doi.org/10.1016/j.clim.2008.01.019
doi: 10.1016/j.clim.2008.01.019
pubmed: 18373953
Xing Q, Wang B, Su H et al (2012) Elevated Th17 cells are accompanied by FoxP3+ Treg cells decrease in patients with lupus nephritis. Rheumatol Int 32(4):949–958. https://doi.org/10.1007/s00296-010-1771-0
doi: 10.1007/s00296-010-1771-0
pubmed: 21243492
Wong CK, Ho CY, Li EK, Lam CWK (2000) Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus. Lupus 9(8):589–593. https://doi.org/10.1191/096120300678828703
doi: 10.1191/096120300678828703
pubmed: 11035433
Doreau A, Belot A, Bastid J et al (2009) Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus. Nat Immunol 10(7):778–785. https://doi.org/10.1038/ni.1741
doi: 10.1038/ni.1741
pubmed: 19483719
Hammad A, Osman E, Mosaad Y, Wahba M (2017) Serum interleukin-17 in Egyptian children with systemic lupus erythematosus: is it related to pulmonary affection? Lupus 26(4):388–395. https://doi.org/10.1177/0961203316665709
doi: 10.1177/0961203316665709
pubmed: 27587461
Gunawan A, Susianti H, Indyanty E et al (2016) The association between G-197A gene polymorphism of IL-17A with changes in protein interaction of IL-17A, levels of urinary IL-17, and degree of lupus nephritis abnormality. Comp Clin Pathol 25:535–541. https://doi.org/10.1007/s00580-016-2222-4
doi: 10.1007/s00580-016-2222-4
Shu Q, Yang P, Hou S et al (2010) Interleukin-17 gene polymorphism is associated with Vogt-Koyanagi-Harada syndrome but not with Behçet’s disease in a Chinese Han population. Hum Immunol 71(10):988–991. https://doi.org/10.1016/j.humimm.2010.06.020
doi: 10.1016/j.humimm.2010.06.020
pubmed: 20620187
Holster A, Teräsjärvi J, Lauhkonen E et al (2018) IL-17A gene polymorphism rs2275913 is associated with the development of asthma after bronchiolitis in infancy. Allergol Int 67(1):109–113. https://doi.org/10.1016/j.alit.2017.05.010
doi: 10.1016/j.alit.2017.05.010
pubmed: 28647382
Xu H, Pan Y, Li W et al (2016) Association between IL17A and IL17F polymorphisms and risk of Henoch-Schonlein purpura in Chinese children. Rheumatol Int 36(6):829–835. https://doi.org/10.1007/s00296-016-3465-8
doi: 10.1007/s00296-016-3465-8
pubmed: 27021337
Ho AW, Gaffen SL (2010) IL-17RC: a partner in IL-17 signaling and beyond. Semin Immunopathol 32(1):33–42. https://doi.org/10.1007/s00281-009-0185-0
doi: 10.1007/s00281-009-0185-0
pubmed: 20012905
Zhou S, Qiu XS, Zhu ZZ, Wu WF, Liu Z, Qiu Y (2012) A single-nucleotide polymorphism rs708567 in the IL-17RC gene is associated with a susceptibility to and the curve severity of adolescent idiopathic scoliosis in a Chinese Han population: a case-control study. BMC Musculoskelet Disord 13:181. https://doi.org/10.1186/1471-2474-13-181
doi: 10.1186/1471-2474-13-181
pubmed: 22999050
pmcid: 3517504
Petri M, Orbai AM, Alarcón GS et al (2012) Derivation and validation of systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum 64(8):2677–2686. https://doi.org/10.1002/art.34473
doi: 10.1002/art.34473
pubmed: 22553077
pmcid: 3409311
Zhao XF, Pan HF, Yuan H et al (2010) Increased serum interleukin 17 in patients with systemic lupus erythematosus. Mol Biol Rep 37(1):81–85. https://doi.org/10.1007/s11033-009-9533-3
doi: 10.1007/s11033-009-9533-3
pubmed: 19347604
Shen HH, Fan YN, Zhao CN et al (2020) Elevated circulating Interleukin-17 levels in patients with systemic lupus erythematosus: a meta-analysis. Immunol Invest 49(6):662–675. https://doi.org/10.1080/08820139.2019.1699107
doi: 10.1080/08820139.2019.1699107
pubmed: 31847623
Vincent FB, Northcott M, Hoi A et al (2013) Clinical associations of serum interleukin-17 in systemic lupus erythematosus. Arthritis Res Ther 15(4):R97. https://doi.org/10.1186/ar4277
doi: 10.1186/ar4277
pubmed: 23968496
pmcid: 3979031
PeliçariKde O, Postal M, Sinicato NA et al (2015) Serum interleukin-17 levels are associated with nephritis in childhood-onset systemic lupus erythematosus. Clinics (Sao Paulo) 70(5):313–317. https://doi.org/10.6061/clinics/2015(05)01
doi: 10.6061/clinics/2015(05)01
Xie M, Cheng B, Ding Y et al (2019) Correlations of IL-17 and NF-κB gene polymorphisms with susceptibility and prognosis in Acute Respiratory Distress Syndrome in a Chinese population. Biosci Rep. https://doi.org/10.1041/BSR20181987
Espinoza JL, Takami A, Nakata K et al (2011) A genetic variant in the IL-17 promoter is functionally associated with acute graft-versus-host disease after unrelated bone marrow transplantation. PLoS ONE 6(10):e26229. https://doi.org/10.1371/journal.pone.0026229
doi: 10.1371/journal.pone.0026229
pubmed: 22028838
pmcid: 3197629
Dhaouadi T, Chahbi M, Haouami Y et al (2018) IL-17A, IL-17RC polymorphisms and IL17 plasma levels in Tunisian patients with rheumatoid arthritis. PLoS ONE 13(3):e0194883. https://doi.org/10.1371/journal.pone.0194883
doi: 10.1371/journal.pone.0194883
pubmed: 29584788
pmcid: 5870983
Montúfar-Robles I, Barbosa-Cobos R, Alemán-Ávila I, Ramírez-Bello J (2019) IL17A haplotype confers susceptibility to systemic lupus erythematosus but not to rheumatoid arthritis in Mexican patients. Int J Rheum Dis 22(3):473–479. https://doi.org/10.1111/1756-185X.13426
doi: 10.1111/1756-185X.13426
pubmed: 30398030
Sharifzadeh M, Naeimi S, Nasiri M et al (2018) IL-17A gene polymorphism at position G197A and systemic lupus erythematosus. Rheumatol Res 3(3):107–112
doi: 10.22631/rr.2018.69997.1050
Paradowska-Gorycka A, Roszak M, Stypinska B et al (2019) IL-6 and TGF-β gene polymorphisms, their serum levels, as well as HLA profile, in patients with systemic lupus erythematosus. Clin Exp Rheumatol 37(6):963–975
pubmed: 30943147
Georgiev T, Stoilov R (2019) Bulgarian Rheumatology: science and practice in a cost-constrained environment. Rheumatol Int 39(3):417–429. https://doi.org/10.1007/s00296-018-4202-2
doi: 10.1007/s00296-018-4202-2
pubmed: 30413925