Simple Esterification of [1-


Journal

ACS chemical biology
ISSN: 1554-8937
Titre abrégé: ACS Chem Biol
Pays: United States
ID NLM: 101282906

Informations de publication

Date de publication:
19 11 2021
Historique:
pubmed: 24 9 2021
medline: 7 1 2022
entrez: 23 9 2021
Statut: ppublish

Résumé

Alpha-ketoglutarate (α-KG) is a key metabolite and signaling molecule in cancer cells, but the low permeability of α-KG limits the study of α-KG mediated effects in vivo. Recently, cell-permeable monoester and diester α-KG derivatives have been synthesized for use in vivo, but many of these derivatives are not compatible for use in hyperpolarized carbon-13 nuclear magnetic resonance spectroscopy (HP-

Identifiants

pubmed: 34554724
doi: 10.1021/acschembio.1c00561
pmc: PMC9107957
mid: NIHMS1787559
doi:

Substances chimiques

Carbon Isotopes 0
Ketoglutaric Acids 0
Glutamine 0RH81L854J
Glutamic Acid 3KX376GY7L

Types de publication

Journal Article Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2144-2150

Subventions

Organisme : NCI NIH HHS
ID : K99 CA222493
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA138292
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA217691
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA222493
Pays : United States

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Auteurs

Jenna E AbuSalim (JE)

Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.
Department of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, United States.

Kazutoshi Yamamoto (K)

Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.

Natsuko Miura (N)

Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.

Burchelle Blackman (B)

Chemistry and Synthesis Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.

Jeffrey R Brender (JR)

Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.

Chandrasekhar Mushti (C)

Chemistry and Synthesis Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.

Tomohiro Seki (T)

Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.

Kevin A Camphausen (KA)

Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.

Rolf E Swenson (RE)

Chemistry and Synthesis Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.

Murali C Krishna (MC)

Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.

Aparna H Kesarwala (AH)

Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.
Department of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, United States.

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Classifications MeSH