Effect of sex and gonadectomy on brain MPTP toxicity and response to dutasteride treatment in mice.
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
/ metabolism
Animals
Castration
Corpus Striatum
/ metabolism
Disease Models, Animal
Dopamine
/ metabolism
Dutasteride
/ administration & dosage
Female
Glial Fibrillary Acidic Protein
/ metabolism
Humans
Male
Mice, Inbred C57BL
Parkinson Disease
/ metabolism
Sex Characteristics
Substantia Nigra
/ metabolism
Dutasteride
Gonadectomy
MPTP
Parkinson's disease
Sex
Journal
Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217
Informations de publication
Date de publication:
15 12 2021
15 12 2021
Historique:
received:
31
05
2021
revised:
27
08
2021
accepted:
03
09
2021
pubmed:
24
9
2021
medline:
30
3
2022
entrez:
23
9
2021
Statut:
ppublish
Résumé
The main neuropathological feature of Parkinson's disease (PD) is degeneration of dopamine (DA) neurons in the substantia nigra (SN); PD prevalence is higher in men, suggesting a role of sex hormones in neuroprotection. This study sought the effects of sex hormones in the brain in a mouse model of PD and modulation of steroid metabolism/synthesis with the 5α-reductase inhibitor dutasteride shown to protect 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) male mice. Male and female mice were gonadectomized (GDX) or SHAM operated. They were treated with vehicle or dutasteride (5 mg/kg) for 10 days and administered a low dose of MPTP (5.5 mg/kg) or saline on the 5th day to model early PD; brains were collected thereafter. Striatal measures of the active metabolite 1-methyl-4-phenylpyridinium (MPP
Identifiants
pubmed: 34555366
pii: S0028-3908(21)00339-7
doi: 10.1016/j.neuropharm.2021.108784
pii:
doi:
Substances chimiques
Glial Fibrillary Acidic Protein
0
glial fibrillary astrocytic protein, mouse
0
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
9P21XSP91P
Dutasteride
O0J6XJN02I
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108784Subventions
Organisme : CIHR
ID : PJT-159680
Pays : Canada
Organisme : CIHR
ID : SVB-158621
Pays : Canada
Informations de copyright
Copyright © 2021. Published by Elsevier Ltd.