What can we learn about amphiphile-membrane interaction from model lipid membranes?
Amphiphilic drugs
Ascorbyl palmitate
Brewster angle microscopy
Langmuir films
Miltefosine
Journal
Biochimica et biophysica acta. Biomembranes
ISSN: 1879-2642
Titre abrégé: Biochim Biophys Acta Biomembr
Pays: Netherlands
ID NLM: 101731713
Informations de publication
Date de publication:
01 02 2022
01 02 2022
Historique:
received:
31
03
2021
revised:
30
08
2021
accepted:
14
09
2021
pubmed:
24
9
2021
medline:
29
12
2021
entrez:
23
9
2021
Statut:
ppublish
Résumé
Surface-active amphiphiles find applications in a wide range of areas of industry such as agrochemicals, personal care, and pharmaceuticals. In many of these applications, interaction with cell membranes is a key factor for achieving their purpose. How do amphiphiles interact with lipid membranes? What are their bases for membrane specificity? Which biophysical properties of membranes are susceptible to modulation by amphiphilic membrane-effectors? What aspects of this interaction are important for performing their function? In our work on membrane biophysics over the years, questions like these have arisen and we now share some of our findings and discuss them in this review. This topic was approached focusing on the membrane properties and their alterations rather than on the amphiphile structure requirements for their interaction. Here, we do not aim to provide a comprehensive list of the modes of action of amphiphiles of biological interest but to help in understanding them.
Identifiants
pubmed: 34555419
pii: S0005-2736(21)00229-7
doi: 10.1016/j.bbamem.2021.183781
pii:
doi:
Substances chimiques
Membrane Lipids
0
Surface-Active Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
183781Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.