Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy.

Antiviral Agents / metabolism Autophagy GTPase-Activating Proteins / genetics Host-Pathogen Interactions Humans Immune Evasion Influenza A virus / pathogenicity Lysosomes / metabolism Protein Binding Viral Matrix Proteins / metabolism Virus Replication rab GTP-Binding Proteins / metabolism rab7 GTP-Binding Proteins

Journal

Nature microbiology
ISSN: 2058-5276
Titre abrégé: Nat Microbiol
Pays: England
ID NLM: 101674869

Informations de publication

Date de publication:
10 2021
Historique:
received: 09 05 2020
accepted: 18 08 2021
pubmed: 25 9 2021
medline: 5 11 2021
entrez: 24 9 2021
Statut: ppublish

Résumé

The fate of influenza A virus (IAV) infection in the host cell depends on the balance between cellular defence mechanisms and viral evasion strategies. To illuminate the landscape of IAV cellular restriction, we generated and integrated global genetic loss-of-function screens with transcriptomics and proteomics data. Our multi-omics analysis revealed a subset of both IFN-dependent and independent cellular defence mechanisms that inhibit IAV replication. Amongst these, the autophagy regulator TBC1 domain family member 5 (TBC1D5), which binds Rab7 to enable fusion of autophagosomes and lysosomes, was found to control IAV replication in vitro and in vivo and to promote lysosomal targeting of IAV M2 protein. Notably, IAV M2 was observed to abrogate TBC1D5-Rab7 binding through a physical interaction with TBC1D5 via its cytoplasmic tail. Our results provide evidence for the molecular mechanism utilised by IAV M2 protein to escape lysosomal degradation and traffic to the cell membrane, where it supports IAV budding and growth.

Identifiants

DOI: 10.1038/s41564-021-00964-2 PMID: 34556855 PMC: PMC9683089
pubmed: 34556855
doi: 10.1038/s41564-021-00964-2
pii: 10.1038/s41564-021-00964-2
pmc: PMC9683089
mid: NIHMS1784713
doi:

Substances chimiques

Antiviral Agents 0
GTPase-Activating Proteins 0
M2 protein, Influenza A virus 0
TBC1D5 protein, human 0
Viral Matrix Proteins 0
rab7 GTP-Binding Proteins 0
rab7 GTP-binding proteins, human 0
rab GTP-Binding Proteins EC 3.6.5.2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1319-1333

Subventions

Organisme : NIAID NIH HHS
ID : HHSN272201400008C
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM103504
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI135990
Pays : United States
Organisme : NIAID NIH HHS
ID : K22 AI136691
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA030199
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI117873
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI106754
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI135972
Pays : United States

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Laura Martin-Sancho (L)

Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.

Shashank Tripathi (S)

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Center for Infectious Disease Research, Microbiology & Cell Biology Department, Indian Institute of Science, Bangalore, India.

Ariel Rodriguez-Frandsen (A)

Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.

Lars Pache (L)

Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
ORCID: 0000-0002-4193-1042

Maite Sanchez-Aparicio (M)

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0001-6556-5924

Michael J McGregor (MJ)

Quantitative Biosciences Institute (QBI), University of California, San Francisco, CA, USA.
Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.
Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes, San Francisco, CA, USA.

Kelsey M Haas (KM)

Quantitative Biosciences Institute (QBI), University of California, San Francisco, CA, USA.
Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.
Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes, San Francisco, CA, USA.
ORCID: 0000-0002-1463-6726

Danielle L Swaney (DL)

Quantitative Biosciences Institute (QBI), University of California, San Francisco, CA, USA.
Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.
Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes, San Francisco, CA, USA.

Thong T Nguyen (TT)

Quantitative Biosciences Institute (QBI), University of California, San Francisco, CA, USA.
Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.
Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes, San Francisco, CA, USA.

João I Mamede (JI)

Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL, USA.
ORCID: 0000-0002-6048-1876

Christopher Churas (C)

Department of Medicine, University of California, San Diego, La Jolla, CA, USA.

Dexter Pratt (D)

Department of Medicine, University of California, San Diego, La Jolla, CA, USA.

Sara B Rosenthal (SB)

Department of Medicine, University of California, San Diego, La Jolla, CA, USA.

Laura Riva (L)

Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.

Courtney Nguyen (C)

Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.

Nish Beltran-Raygoza (N)

Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.

Stephen Soonthornvacharin (S)

Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.

Guojun Wang (G)

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

David Jimenez-Morales (D)

Quantitative Biosciences Institute (QBI), University of California, San Francisco, CA, USA.
Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.
Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes, San Francisco, CA, USA.
Department of Medicine, Division of Cardiovascular Medicine, Stanford University, Stanford, CA, USA.
ORCID: 0000-0003-4356-6461

Paul D De Jesus (PD)

Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.

Hong M Moulton (HM)

Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA.

David A Stein (DA)

Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA.

Max W Chang (MW)

Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
ORCID: 0000-0002-4526-489X

Chris Benner (C)

Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
ORCID: 0000-0002-4618-0719

Trey Ideker (T)

Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA, USA.
ORCID: 0000-0002-1708-8454

Randy A Albrecht (RA)

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0003-4008-503X

Judd F Hultquist (JF)

Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.
Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Nevan J Krogan (NJ)

Quantitative Biosciences Institute (QBI), University of California, San Francisco, CA, USA.
Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.
Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes, San Francisco, CA, USA.
ORCID: 0000-0003-4902-337X

Adolfo García-Sastre (A)

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
The Tisch Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-6551-1827

Sumit K Chanda (SK)

Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. schanda@sbpdiscovery.org.
ORCID: 0000-0001-9399-7927

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Restriction factor compendium for influenza A...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › Restriction factor compendium for influenza A...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Régulateurs des protéines G › Protéines d'activation de la GTPase › Restriction factor compendium for influenza A...
questionsmedicales.fr › Phénomènes biologiques › Interactions hôte-microbes › Interactions hôte-pathogène › Restriction factor compendium for influenza A...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Restriction factor compendium for influenza A...
questionsmedicales.fr › Phénomènes biologiques › Interactions hôte-microbes › Interactions hôte-pathogène › Échappement immunitaire › Restriction factor compendium for influenza A...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Orthomyxoviridae › Influenzavirus A › Virus de la grippe A › Restriction factor compendium for influenza A...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Lysosomes › Restriction factor compendium for influenza A...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Restriction factor compendium for influenza A...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines de l'enveloppe virale › Protéines de la matrice virale › Restriction factor compendium for influenza A...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › Restriction factor compendium for influenza A...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Protéines G monomériques › Protéines G rab › Restriction factor compendium for influenza A...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Protéines G monomériques › Protéines G rab › Protéines Rab7 liant le GTP › Restriction factor compendium for influenza A...