Thromboxane A
blood pressure
cyclooxygenase
mechanoreflex
muscle afferents
sensory neurons
Journal
Physiological reports
ISSN: 2051-817X
Titre abrégé: Physiol Rep
Pays: United States
ID NLM: 101607800
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
revised:
30
08
2021
received:
30
08
2021
accepted:
02
09
2021
entrez:
24
9
2021
pubmed:
25
9
2021
medline:
1
3
2022
Statut:
ppublish
Résumé
Mechanical and metabolic signals associated with skeletal muscle contraction stimulate the sensory endings of thin fiber muscle afferents and produce reflex increases in sympathetic nerve activity and blood pressure during exercise (i.e., the exercise pressor reflex; EPR). The EPR is exaggerated in patients and animals with heart failure with reduced ejection fraction (HF-rEF) and its activation contributes to reduced exercise capacity within this patient population. Accumulating evidence suggests that the exaggerated EPR in HF-rEF is partially attributable to a sensitization of mechanically activated channels produced by thromboxane A
Identifiants
pubmed: 34558221
doi: 10.14814/phy2.15052
pmc: PMC8461035
doi:
Substances chimiques
Receptors, Thromboxane A2, Prostaglandin H2
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e15052Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL142877
Pays : United States
Organisme : NHLBI NIH HHS
ID : F31 HL154779
Pays : United States
Informations de copyright
© 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.
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