A pre-specified analysis of the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) randomized controlled trial on the incidence of abrupt declines in kidney function.


Journal

Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470

Informations de publication

Date de publication:
01 2022
Historique:
received: 19 04 2021
revised: 26 08 2021
accepted: 03 09 2021
pubmed: 25 9 2021
medline: 12 3 2022
entrez: 24 9 2021
Statut: ppublish

Résumé

This pre-specified analysis of DAPA-CKD assessed the impact of sodium-glucose cotransporter 2 inhibition on abrupt declines in kidney function in high-risk patients based on having chronic kidney disease (CKD) and substantial albuminuria. DAPA-CKD was a randomized, double-blind, placebo-controlled trial that had a median follow-up of 2.4 years. Adults with CKD (urinary albumin-to-creatinine ratio 200-5000 mg/g and estimated glomerular filtration rate 25-75 mL/min/1.73m

Identifiants

pubmed: 34560136
pii: S0085-2538(21)00865-6
doi: 10.1016/j.kint.2021.09.005
pii:
doi:

Substances chimiques

Benzhydryl Compounds 0
Glucosides 0
Sodium-Glucose Transporter 2 Inhibitors 0
dapagliflozin 1ULL0QJ8UC

Types de publication

Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

174-184

Investigateurs

Hiddo J L Heerspink (HJL)
David C Wheeler (DC)
Glenn Chertow (G)
Ricardo Correa-Rotter (R)
Tom Greene (T)
Fan Fan Hou (FF)
John McMurray (J)
Peter Rossing (P)
Robert Toto (R)
Bergur Stefansson (B)
Anna Maria Langkilde (AM)
L E Maffei (LE)
P Raffaele (P)
S E Solis (SE)
C A Arias (CA)
D Aizenberg (D)
C Luquez (C)
C Zaidman (C)
N Cluigt (N)
M Mayer (M)
A Alvarisqueta (A)
A Wassermann (A)
R Maldonado (R)
J Bittar (J)
M Maurich (M)
L E Gaite (LE)
N Garcia (N)
L Sivak (L)
P O Ramallo (PO)
J C Santos (JC)
R Garcia Duran (R)
J A Oddino (JA)
A Maranon (A)
L N Maia (LN)
D D Avila (DD)
E J G Barros (EJG)
M H Vidotti (MH)
D Panarotto (D)
I D L Noronha (IDL)
L A A Turatti (LAA)
L Deboni (L)
M E Canziani (ME)
M C Riella (MC)
M R Bacci (MR)
R P Paschoalin (RP)
R J Franco (RJ)
J C Goldani (JC)
E St-Amour (E)
A W Steele (AW)
R Goldenberg (R)
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Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2021 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

Auteurs

Hiddo J L Heerspink (HJL)

Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; The George Institute for Global Health, Sydney, Australia. Electronic address: h.j.lambers.heerspink@umcg.nl.

David Cherney (D)

Department of Medicine, Division of Nephrology, University Health Network and University of Toronto, Toronto, Canada.

Douwe Postmus (D)

Department of Epidemiology, University of Groningen, University Medical Centre Groningen, the Netherlands.

Bergur V Stefánsson (BV)

Late-Stage Development, Cardiovascular, Renal, and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.

Glenn M Chertow (GM)

Department of Medicine and Epidemiology and Population Health, Stanford University School of Medicine, Stanford, USA.

Jamie P Dwyer (JP)

Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Tom Greene (T)

Study Design and Biostatistics Center, University of Utah Health Sciences, Salt Lake City, Utah, USA.

Mikhail Kosiborod (M)

The George Institute for Global Health, Sydney, Australia; Saint Luke's Mid America Heart Institute, University of Missouri, Kansas City, Missouri, USA.

Anna Maria Langkilde (AM)

Late-Stage Development, Cardiovascular, Renal, and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.

John J V McMurray (JJV)

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.

Ricardo Correa-Rotter (R)

The National Medical Science and Nutrition Institute Salvador Zubiran, Mexico City, Mexico.

Peter Rossing (P)

Steno Diabetes Center Copenhagen, Gentofte, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

C David Sjöström (CD)

Late-Stage Development, Cardiovascular, Renal, and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.

Robert D Toto (RD)

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

David C Wheeler (DC)

The George Institute for Global Health, Sydney, Australia; Department of Renal Medicine, University College London, London, UK.

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