Sphk1 promotes salivary adenoid cystic carcinoma progression via PI3K/Akt signaling.

Apoptosis Carcinoma, Adenoid Cystic / enzymology Cell Line, Tumor Cell Movement Cell Proliferation Disease Progression Epithelial-Mesenchymal Transition Gene Expression Regulation, Neoplastic Humans Phosphatidylinositol 3-Kinase / metabolism Phosphorylation Phosphotransferases (Alcohol Group Acceptor) / genetics Proto-Oncogene Proteins c-akt / metabolism Salivary Gland Neoplasms / enzymology Signal Transduction
PI3K/Akt Proliferation Salivary adenoid cystic carcinoma Sphk1 Tumorigenesis

Journal

Pathology, research and practice
ISSN: 1618-0631
Titre abrégé: Pathol Res Pract
Pays: Germany
ID NLM: 7806109

Informations de publication

Date de publication:
Nov 2021
Historique:
received: 27 07 2021
revised: 06 09 2021
accepted: 10 09 2021
pubmed: 25 9 2021
medline: 3 3 2022
entrez: 24 9 2021
Statut: ppublish

Résumé

The progression of salivary adenoid cystic carcinoma (SACC) is closely related to abnormal gene expression. Herein, the role of Sphk1 in SACC was explored. Sphk1 was overexpressed in SACC tissues. In SACC cell lines, Sphk1 induced cell proliferation, inhibited apoptosis, and promoted cell migration. Moreover, Sphk1 overexpression induced up-regulation of the PI3K protein level and AKT phosphorylation level. Rescue assays further showed that activation of the Sphk1 /PI3K/Akt pathway affected various biological functions of SACC cells. Together, these findings suggested that Sphk1 promotes salivary tumorigenesis by activating the PI3K/ Akt pathway, which may provide novel intervention targets for SACC treatment.

Identifiants

DOI: 10.1016/j.prp.2021.153620 PMID: 34560416
pubmed: 34560416
pii: S0344-0338(21)00281-8
doi: 10.1016/j.prp.2021.153620
pii:
doi:

Substances chimiques

Phosphotransferases (Alcohol Group Acceptor) EC 2.7.1.-
sphingosine kinase EC 2.7.1.-
Phosphatidylinositol 3-Kinase EC 2.7.1.137
Proto-Oncogene Proteins c-akt EC 2.7.11.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

153620

Informations de copyright

Copyright © 2021 Elsevier GmbH. All rights reserved.

Auteurs

Chen-Xing Hou (CX)

Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing 210029, China; Depatment of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing 210029, China.

Li Wang (L)

Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing 210029, China; Department of Stomatology, Wuxi Huishan District People's Hospital, Wuxi 214187, China.

Man Cai (M)

Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing 210029, China; Department of Stomatology, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian 223800, China.

Ying Meng (Y)

Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing 210029, China; Depatment of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing 210029, China.

Yu-Ting Tang (YT)

Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing 210029, China; Depatment of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing 210029, China.

Qing-Hai Zhu (QH)

Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing 210029, China; Depatment of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing 210029, China.

Wei Han (W)

Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing 210029, China; Depatment of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing 210029, China.

Nan-Nan Sun (NN)

Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing 210029, China; Depatment of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing 210029, China.

Ben Ma (B)

Department of Stomatology, The Affiliated Suzhou Science & Technology Town Hospital of Nanjing Medical University, Suzhou 215153, China.

Yong Hu (Y)

Department of Stomatology, The Affiliated Suzhou Science & Technology Town Hospital of Nanjing Medical University, Suzhou 215153, China.

Jin-Hai Ye (JH)

Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing 210029, China; Depatment of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing 210029, China. Electronic address: yejinhai@njmu.edu.cn.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Sphk1 promotes salivary adenoid cystic...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Adénocarcinome › Carcinome adénoïde kystique › Sphk1 promotes salivary adenoid cystic...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Sphk1 promotes salivary adenoid cystic...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Sphk1 promotes salivary adenoid cystic...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Sphk1 promotes salivary adenoid cystic...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Sphk1 promotes salivary adenoid cystic...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transdifférenciation cellulaire › Transition épithélio-mésenchymateuse › Sphk1 promotes salivary adenoid cystic...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Sphk1 promotes salivary adenoid cystic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Sphk1 promotes salivary adenoid cystic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphatidylinositol 3-kinases › Phosphatidylinositol 3-kinase › Sphk1 promotes salivary adenoid cystic...
questionsmedicales.fr › Métabolisme › Phosphorylation › Sphk1 promotes salivary adenoid cystic...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Alcohol Group Acceptor) › Sphk1 promotes salivary adenoid cystic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-akt › Sphk1 promotes salivary adenoid cystic...
questionsmedicales.fr › Maladies du système stomatognathique › Maladies de la bouche › Maladies de la glande salivaire › Tumeurs des glandes salivaires › Sphk1 promotes salivary adenoid cystic...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Sphk1 promotes salivary adenoid cystic...